Gene interactions and pathways from curated databases and text-mining

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FOXO1 — SIRT2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., Aging Cell 2007 : SIRT2 hence increases FOXO DNA binding and elevates the expression of FOXO target genes, p27 ( Kip1 ), manganese superoxide dismutase and Bim
Oh et al., Mol Pharmacol 2010 : In addition, SIRT1 inhibition reduced both nuclear FoxO1 levels and MDR1 expression in doxorubicin-resistant breast cancer cells ( MCF-7/ADR ) cells