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FOXO1 — SIRT2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Wang et al., Aging Cell 2007
:
SIRT2 hence
increases FOXO DNA binding and elevates the expression of FOXO target genes, p27 ( Kip1 ), manganese superoxide dismutase and Bim
Oh et al., Mol Pharmacol 2010
:
In addition,
SIRT1 inhibition
reduced both nuclear
FoxO1 levels and MDR1 expression in doxorubicin-resistant breast cancer cells ( MCF-7/ADR ) cells