Gene interactions and pathways from curated databases and text-mining

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PRKAA1 — SIRT3

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Shi et al., J Dig Dis 2010 : The activation of AMPK by SIRT3 was dependent on SIRT3 deacetylase activity
Shulga et al., J Cell Sci 2010 : Moreover, activation of AMPK , a known positive modulator of sirtuin activity, prevented the ethanol induced suppression of sirtuin-3 activity and the attendant increase of cyclophilin-D acetylation, activity and association with ANT-1
Caton et al., Diabetes Obes Metab 2011 (Disease Models, Animal...) : Metformin increased AMPK activity in WAT of db/db mice and in metformin treated adipocytes, with increased NAMPT, SIRT1 and circadian component expression
Li et al., Basic Res Cardiol 2011 : Parallel to these changes, we observed AMPK activation, SIRT1 induction and PGC-1a deacetylation
Greco et al., Biochem Biophys Res Commun 2011 (Alzheimer Disease) : To this end, we investigated the extent to which activation of AMPK as well as another class of sensors linking energy availability to cellular metabolism, the sirtuins ( SIRT ) , mediate Leptin 's biological activity
Tillu et al., Molecular pain 2012 (Acute Pain...) : Our results demonstrate that resveratrol profoundly inhibits ERK and mTOR signaling in sensory neurons in a time- and concentration dependent fashion and that these effects are mediated by AMPK activation and independent of sirtuin activity
Peserico et al., Cell Mol Life Sci 2013 : A novel AMPK dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels