Gene interactions and pathways from curated databases and text-mining

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FOXO1 — SKP2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Huang et al., Proc Natl Acad Sci U S A 2005 (Lymphoma) : Skp2 inhibits FOXO1 in tumor suppression through ubiquitin mediated degradation ... Here we demonstrate that Skp2 , an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex, interacts with, ubiquitinates, and promotes the degradation of FOXO1 ... This effect of Skp2 requires Akt-specific phosphorylation of FOXO1 at Ser-256
Ward et al., Endocrinology 2008 (Endometrial Neoplasms) : Using small interfering RNA technology, we demonstrated that the low levels of FOXO1 protein were due to the involvement of Skp2, an oncogenic subunit of the Skp1/Cul1/F-box protein ubiquitin complex, given that silencing Skp2 increased FOXO1 protein expression in Ishikawa cells