Gene interactions and pathways from curated databases and text-mining

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AKT2 — SLC25A16

Text-mined interactions from Literome

Burrows et al., J Clin Endocrinol Metab 2011 (Carcinoma...) : In vivo, GDC-0941 reduced expression of HIF-1a, phospho-AKT , GLUT-1, and lactate dehydrogenase A in FTC xenografts
Lin et al., Clin Cancer Res 2013 (Disease Models, Animal...) : Targeting activated Akt with GDC-0068 , a novel selective Akt inhibitor that is efficacious in multiple tumor models ... We describe the preclinical pharmacology and antitumor activity of GDC-0068 , a novel highly selective ATP-competitive pan-Akt inhibitor currently in clinical trials for the treatment of human cancers ... The effect of GDC-0068 on Akt signaling was characterized using specific biomarkers of the Akt pathway, and response to GDC-0068 was evaluated in human cancer cell lines and xenograft models with various genetic backgrounds, either as a single agent or in combination with chemotherapeutic agents ... GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor xenograft models as evidenced by dose dependent decrease in phosphorylation of downstream targets