Gene interactions and pathways from curated databases and text-mining

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PIK3CA — SLC25A16

Text-mined interactions from Literome

Wallin et al., Sci Transl Med 2010 (Breast Neoplasms...) : We used preclinical cancer models to determine the effects of combining the DNA damaging drug doxorubicin with GDC-0941 , a class I PI3K inhibitor that is currently being tested in early-stage clinical trials
Wallin et al., Clin Cancer Res 2012 (Breast Neoplasms...) : GDC-0941 , a novel class I selective PI3K inhibitor , enhances the efficacy of docetaxel in human breast cancer models by increasing cell death in vitro and in vivo ... The current study was intended to determine whether GDC-0941 , an orally bioavailable class I selective PI3K inhibitor , enhances the antitumor activity of docetaxel in human breast cancer models in vitro and in vivo
Junttila et al., Cancer Cell 2009 (Breast Neoplasms) : Ligand independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
Yuan et al., Oncogene 2013 (Adenocarcinoma...) : Further, we used this model to test the efficacy of GDC-0941 , a PI3K inhibitor , in clinical development, and showed that the tumors respond to PI3K inhibition
Yao et al., Clin Cancer Res 2009 (Breast Neoplasms) : We therefore investigated the combinatorial activity of GDC-0941 , a novel class I PI3K inhibitor , with standard-of-care therapies for HER2 amplified breast cancer
Sampath et al., Neoplasia (New York, N.Y.) 2013 : GDC-0980 , a dual PI3K/mTOR inhibitor , was found to reduce micro-CT angiography vascular density, while VSI MRI demonstrated a significant reduction in vessel density and an increase in mean vessel size, consistent with a loss of small functional vessels and a substantial antivascular response
Lin et al., Int J Cancer 2013 (Brain Neoplasms...) : Palomid 529 lacked affinity for these transporters in vitro, in contrast to GDC-0941 , a small molecule PI3K inhibitor , which we used as control substance for in vitro transport