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AKT1 — SLC2A1

Text-mined interactions from Literome

Barthel et al., J Biol Chem 1999 (Liver Neoplasms, Experimental) : We used mouse hepatoma ( Hepa1c1c7 ) cells to study the role of the serine/threonine kinase Akt in the induction of GLUT1 gene expression ... Furthermore, expression of a kinase-inactive Akt mutant partially inhibits the response of the GLUT1 gene to insulin
Palmada et al., Diabetes 2006 : The effect on GLUT4 but not on GLUT1 is mediated by activation of protein kinase B (PKB)
Kim et al., Life Sci 2007 : The involvement of phosphatidylinositol 3-kinase /Akt signaling in high glucose induced downregulation of GLUT-1 expression in ARPE cells ... The high glucose induced downregulation of GLUT-1 was blocked by Wortmanin, LY 294002 ( PI-3 kinase inhibitors ) and Akt ( Akt inhibitor )
Wieman et al., Mol Biol Cell 2007 : Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking ... To determine how Akt may regulate Glut1 , we analyzed the role of Akt activation of mammalian target of rapamycin (mTOR)/regulatory associated protein of mTOR ( RAPTOR ) and inhibition of glycogen synthase kinase ( GSK ) 3 ... These data demonstrate that intracellular trafficking of Glut1 is a regulated component of growth factor stimulated glucose uptake and that Akt can promote Glut1 activity and recycling as well as prevent Glut1 internalization
Fernandes et al., Am J Physiol Cell Physiol 2011 : Furthermore, data indicate that protein kinase B activation is involved in the stabilization of GLUT1 at the plasma membrane
Nozaki et al., Cell Signal 2013 : Insulin induced, but not constitutively activated Rac1 induced, GLUT4 translocation was suppressed by Akt inhibitor IV