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IL21 — SMAD3

Text-mined interactions from Literome

Verrecchia et al., J Biol Chem 2003 : We demonstrate that, in a cellular context devoid of JNK activity ( i.e. jnk ( -/- ) fibroblasts ), interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) did not inhibit the formation of SMAD-DNA complexes and the resulting SMAD-driven transcription in response to TGF-beta
Xiao et al., J Immunol 2008 (Autoimmune Diseases) : Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of Smad3 , and this results in increased Foxp3 expression even in the presence of IL-6 or IL-21