Gene interactions and pathways from curated databases and text-mining

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FOXO1 — SOD2

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: SOD2 → FOXO1 (increases, SOD2 Activity) Abid et al., J Biol Chem 2006*
    Evidence: The data revealed the existence of a novel set of VEGF-responsive genes that require FKHR activity for optimal expression in ECs, including bone morphogenic protein 2, cbp/p300-interacting transactivator 2, decay accelerating factor (DAF), vascular cell adhesion molecule-1 (VCAM-1), manganese superoxide dismutase, endothelial-specific molecule-1, RING1 and YY1 binding protein, and matrix metalloproteinase-10 and MGC5618
  • OpenBEL Selventa BEL large corpus: SOD2 → FOXO1 (increases, SOD2 Activity)
    Evidence: Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]
  • NCI Pathway Database FoxO family signaling: FOXO1/SIRT1 complex (FOXO1-SIRT1) → MNSOD (SOD2) (transcription, activates) Daitoku et al., Proc Natl Acad Sci U S A 2004*
    Evidence: mutant phenotype, other species

Text-mined interactions from Literome

Fallarino et al., J Exp Med 2004 : IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the Forkhead Box class O ( FOXO ) transcription factor FOXO3a, induction of the superoxide dismutase gene, and prevention of peroxynitrite formation
Adachi et al., Gastroenterology 2007 (Liver Cirrhosis, Experimental...) : FoxO1 directly induces the expression of p27 ( kip1 ) and manganese superoxide dismutase ( MnSOD )