◀ Back to FOXO1
FOXO1 — SOD2
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
SOD2
→
FOXO1
(increases, SOD2 Activity)
Abid et al., J Biol Chem 2006*
Evidence: The data revealed the existence of a novel set of VEGF-responsive genes that require FKHR activity for optimal expression in ECs, including bone morphogenic protein 2, cbp/p300-interacting transactivator 2, decay accelerating factor (DAF), vascular cell adhesion molecule-1 (VCAM-1), manganese superoxide dismutase, endothelial-specific molecule-1, RING1 and YY1 binding protein, and matrix metalloproteinase-10 and MGC5618
-
OpenBEL Selventa BEL large corpus:
SOD2
→
FOXO1
(increases, SOD2 Activity)
Evidence: Supplemental Table S2. Transcripts found in Class IIa [induced by FKHR] Supplemental Table S3. Transcripts found in Class IIb [induced by FKHR]
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NCI Pathway Database FoxO family signaling:
FOXO1/SIRT1 complex (FOXO1-SIRT1)
→
MNSOD (SOD2)
(transcription, activates)
Daitoku et al., Proc Natl Acad Sci U S A 2004*
Evidence: mutant phenotype, other species
Text-mined interactions from Literome
Fallarino et al., J Exp Med 2004
:
IFN-gamma-driven expression of tryptophan catabolism by CTLA-4-immunoglobulin is made possible through the concomitant activation of the
Forkhead Box class O ( FOXO ) transcription factor FOXO3a,
induction of the
superoxide dismutase gene, and prevention of peroxynitrite formation
Adachi et al., Gastroenterology 2007
(Liver Cirrhosis, Experimental...) :
FoxO1 directly
induces the expression of p27 ( kip1 ) and manganese
superoxide dismutase ( MnSOD )