Gene interactions and pathways from curated databases and text-mining

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IL21 — SPP1

Text-mined interactions from Literome

Koguchi et al., Infect Immun 2002 (AIDS-Related Opportunistic Infections) : Penicillium marneffei causes osteopontin mediated production of interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Diao et al., Cytokine 2012 (Drug-Induced Liver Injury...) : Osteopontin regulates interleukin-17 production in hepatitis
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes