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IL6 — SPP1
Text-mined interactions from Literome
Koguchi et al., Infect Immun 2002
(AIDS-Related Opportunistic Infections) :
Penicillium marneffei causes
osteopontin mediated production of
interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002
(Ossification, Heterotopic) :
In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ),
interleukin (IL)-1beta , and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression
Cho et al., Calcif Tissue Int 2007
(Inflammation) :
The mRNA expression of COL1A1 and
osteopontin were not changed by IL-6 or its blocking antibody, but the alkaline phosphatase activities of MC3T3-E1 cells were
increased by
IL-6 and decreased by its blocking antibody
Mas et al., Mult Scler 2007
(Genetic Predisposition to Disease...) :
OPN enhances the production of the pro-inflammatory cytokines,
interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Take et al., Arthritis Rheum 2009
(Arthritis, Rheumatoid...) :
In cocultures of FLS and B lymphocytes, the
effects of
OPN on adhesion of B lymphocytes to FLS and the consequent production of
interleukin-6 (IL-6) were analyzed in experiments involving overexpression and knockdown of OPN and inhibitory studies with an OPN blocking antibody ... Moreover,
OPN overexpression
enhanced production of
IL-6 in 75-kd OPN positive FLS-B lymphocyte cocultures
Samuvel et al., J Biol Chem 2010
:
In our studies to explore the underlying mechanism, we found that the neutralizing antibodies against interleukin (IL)-6 or IL-6 small interfering RNA transfection in adipocytes effectively inhibited coculture stimulated osteopontin expression, suggesting that
IL-6 released by adipocytes
plays an essential role in the coculture stimulated
osteopontin expression by U937 cells
Diao et al., Scand J Infect Dis 2011
(Streptococcal Infections) :
We also found that
OPN production was
suppressed by
interleukin-6 and enhanced by tumour necrosis factor-alpha in immunocompetent cells
Pini et al., J Leukoc Biol 2012
(Inflammation...) :
In DIO mice, production of
OPN and TIMP-1 was increased for a prolonged period, and this was
mediated by
IL-6 in the liver but not the pancreas
Diao et al., Cytokine 2012
(Drug-Induced Liver Injury...) :
Osteopontin regulates
interleukin-17 production in hepatitis
Singh et al., J Biol Chem 1995
:
In vitro,
interleukin-1 beta and interferon-gamma
increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes
Kozawa et al., FEBS Lett 1997
:
In the present study, we further investigated the mechanism of
IL-6 synthesis
induced by
SPP in MC3T3-E1 cells ... PD98059, an inhibitor of MAP kinase kinase, suppressed
SPP induced
IL-6 synthesis as well as SPP induced MAP kinase activation ... TMB-8, an inhibitor of Ca2+ mobilization from intracellular Ca2+ stores, significantly suppressed the
SPP induced
IL-6 synthesis ... These results strongly suggest that
SPP induced
IL-6 synthesis is mediated via p42/p44 MAP kinase activation in osteoblast-like cells and that the SPP induced IL-6 synthesis is dependent on intracellular Ca2+ mobilization
Matsumoto et al., Int Immunol 1998
(Leukemia, Monocytic, Acute) :
Inducible expression of nuclear factor
IL-6 increases endogenous gene expression of macrophage inflammatory protein-1 alpha,
osteopontin and CD14 in a monocytic leukemia cell line ... We demonstrated that inducible expression of
NF-IL6 is able to
increase endogenous gene expression of macrophage inflammatory protein (MIP)-1 alpha,
osteopontin and CD14 in M1 cells