◀ Back to GNB1
GNB1 — SRC
Pathways - manually collected, often from reviews:
-
NCI Pathway Database CXCR4-mediated signaling events:
Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN)
→
G beta/gamma complex (GNB1-GNG2)
(modification, activates)
Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Plasma membrane estrogen receptor signaling:
ER alpha/Gai/GDP/Gbeta gamma complex (ESR1-GNAI2_GNAI3_GNAO1_GNAO1_GNAZ_GNAI1-GNB1-GNG2)
→
Src (SRC)
(modification, activates)
Kumar et al., Mol Endocrinol 2007
Evidence: mutant phenotype
-
NCI Pathway Database CXCR3-mediated signaling events:
G beta/gamma complex (GNB1-GNG2)
→
Src (SRC)
(modification, activates)
Bonacchi et al., J Biol Chem 2001
Evidence: assay
Text-mined interactions from Literome
Piiper et al., Mol Pharmacol 2000
:
Activation of extracellular regulated kinases 1 and 2 ( ERK1/2 ) by G protein coupled receptors has been described to occur either through a PTx-insensitive pathway involving activation of phospholipase C and protein kinase C ( PKC ), or through a PTx-sensitive pathway involving
G(i)betagamma mediated
activation of
Src
Canet-Aviles et al., Brain Res Mol Brain Res 2002
(Alzheimer Disease...) :
These data are discussed in relation to a pathway for the enhancement of sAPPalpha secretion by muscarine which involves the
activation of a
Src-TK by
G-protein beta/gamma-subunits leading to activation of PKCalpha, and ERK1/2 by a mechanism not involving phospholipase C