◀ Back to HNRNPK
HNRNPK — SRC
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
HNRNPK
→
SRC
(directlyIncreases, HNRNPK Activity)
Ostareck-Lederer et al., Mol Cell Biol 2002*
Evidence: We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro. c-Src-mediated phosphorylation reversibly inhibits the binding of hnRNP K to the differentiation control element (DICE) of the LOX mRNA 3' untranslated region in vitro and specifically derepresses the translation of DICE-bearing mRNAs in vivo.
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OpenBEL Selventa BEL large corpus:
SRC
→
Complex of HNRNPK-SRC
(directlyIncreases, HNRNPK/SRC Activity)
Ostareck-Lederer et al., Mol Cell Biol 2002*
Evidence: We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro. c-Src-mediated phosphorylation reversibly inhibits the binding of hnRNP K to the differentiation control element (DICE) of the LOX mRNA 3' untranslated region in vitro and specifically derepresses the translation of DICE-bearing mRNAs in vivo.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
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IRef Bind Interaction:
SRC
—
HNRNPK
Bunnell et al., J Biol Chem 1996*
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IRef Bind_translation Interaction:
SRC
—
HNRNPK
(affinity chromatography technology)
Bunnell et al., J Biol Chem 1996*
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IRef Hprd Interaction:
SRC
—
HNRNPK
(in vitro)
Ostareck-Lederer et al., Mol Cell Biol 2002*, Weng et al., Mol Cell Biol 1994*
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IRef Hprd Interaction:
SRC
—
HNRNPK
(in vivo)
Ostareck-Lederer et al., Mol Cell Biol 2002*, Weng et al., Mol Cell Biol 1994*
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IRef Intact Interaction:
SRC
—
HNRNPK
(physical association, bimolecular fluorescence complementation)
Adolph et al., Mol Cell Biol 2007*
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IRef Intact Interaction:
SRC
—
HNRNPK
(direct interaction, pull down)
Adolph et al., Mol Cell Biol 2007*
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IRef Intact Interaction:
SRC
—
HNRNPK
(physical association, anti tag coimmunoprecipitation)
Adolph et al., Mol Cell Biol 2007*
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IRef Ophid Interaction:
SRC
—
HNRNPK
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ostareck-Lederer et al., Mol Cell Biol 2002
:
c-Src mediated phosphorylation of
hnRNP K drives translational activation of specifically silenced mRNAs
Adolph et al., Mol Cell Biol 2007
:
Here we address the question how
hnRNP K interacts with and
activates c-Src
Feliers et al., American journal of physiology. Renal physiology 2007
:
Src inhibition using PP2 or RNA interference inhibited PKCdelta activity and
prevented hnRNP K phosphorylation on both tyrosine and serine residues and its binding to VEGF mRNA