Gene interactions and pathways from curated databases and text-mining

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HNRNPK — SRC

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: HNRNPK → SRC (directlyIncreases, HNRNPK Activity) Ostareck-Lederer et al., Mol Cell Biol 2002*
    Evidence: We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro. c-Src-mediated phosphorylation reversibly inhibits the binding of hnRNP K to the differentiation control element (DICE) of the LOX mRNA 3' untranslated region in vitro and specifically derepresses the translation of DICE-bearing mRNAs in vivo.
  • OpenBEL Selventa BEL large corpus: SRC → Complex of HNRNPK-SRC (directlyIncreases, HNRNPK/SRC Activity) Ostareck-Lederer et al., Mol Cell Biol 2002*
    Evidence: We show that hnRNP K and the c-Src kinase specifically interact with each other, leading to c-Src activation and tyrosine phosphorylation of hnRNP K in vivo and in vitro. c-Src-mediated phosphorylation reversibly inhibits the binding of hnRNP K to the differentiation control element (DICE) of the LOX mRNA 3' untranslated region in vitro and specifically derepresses the translation of DICE-bearing mRNAs in vivo.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ostareck-Lederer et al., Mol Cell Biol 2002 : c-Src mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs
Adolph et al., Mol Cell Biol 2007 : Here we address the question how hnRNP K interacts with and activates c-Src
Feliers et al., American journal of physiology. Renal physiology 2007 : Src inhibition using PP2 or RNA interference inhibited PKCdelta activity and prevented hnRNP K phosphorylation on both tyrosine and serine residues and its binding to VEGF mRNA