Gene interactions and pathways from curated databases and text-mining

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SST — TNF

Text-mined interactions from Literome

Ohtake et al., Int J Immunopharmacol 2000 (Lung Diseases...) : Although SST had no effect on lung TNF-alpha or IL-1beta level, it increased IL-6
Chowers et al., J Immunol 2000 : Somatostatin through its specific receptor inhibits spontaneous and TNF-alpha- and bacteria induced IL-8 and IL-1 beta secretion from intestinal epithelial cells
Jambrik et al., Intensive Care Med 2002 (Pancreatitis, Acute Necrotizing...) : Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while somatostatin prevented TNFalpha release ( IL-6 : Group ANP : 0, 0, 518+/-139, 956+/-125, 373+/-48, and 122+/-37 pg/ml ; Group S-ANP : 0, 0, 191+/-68, 261+/-49, 23+/-13, and 0 pg/ml ; TNFalpha : Group ANP : 88+/-42, 371+/-40, 2963+/-291, 276+/-30, 197+/-106, and 23+/-14 U/l ; Group S-ANP : 91+/-34, 41+/-25, 68+/-42, 25+/-9, 0, and 0 U/ml )
Yan et al., J Surg Res 2005 : The objective of this study was to determine the expression of somatostatin (SST) and its receptors ( SSTRs ) and their regulation by TNF-alpha as well as cell proliferation in response to SST in human endothelial cells ... TNF-alpha ( 1 ng/ml ) reduced SST , SSTR-1, SSTR-2, and SSTR-5 by 93, 51, 85, and 99 %, respectively, compared to controls ( P < 0.001, t test )
Zhu et al., Zhonghua Yi Xue Za Zhi 2007 (Disease Models, Animal...) : [ The effects of somatostatin on serum interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide induced septic shock : experiment with rats ] ... To explore the effect of somatostatin on serum interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS) induced septic shock ... Somatostatin can inhibit the level of serum IL-6 and TNF-alpha in septic shock induced by LPS and improve the survival rate
Beales et al., Gastroenterology 1997 : The aim of this study was to examine whether IL-8 and TNF-alpha could regulate somatostatin release from isolated canine gastric D cells
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ), somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people ... The TNF alpha production was stimulated by NPY and somatostatin in young subjects, and by NPY, somatostatin and VIP in old ones, whereas GRP produced a decrease of TNF alpha in young persons