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SST — TNF
Text-mined interactions from Literome
Ohtake et al., Int J Immunopharmacol 2000
(Lung Diseases...) :
Although
SST had no effect on lung
TNF-alpha or IL-1beta level, it increased IL-6
Chowers et al., J Immunol 2000
:
Somatostatin through its specific receptor
inhibits spontaneous and
TNF-alpha- and bacteria induced IL-8 and IL-1 beta secretion from intestinal epithelial cells
Jambrik et al., Intensive Care Med 2002
(Pancreatitis, Acute Necrotizing...) :
Plasma level of IL-6 was increased significantly 3 h after pancreatitis induction, but to a lesser extent in Group S-ANP, while
somatostatin prevented
TNFalpha release ( IL-6 : Group ANP : 0, 0, 518+/-139, 956+/-125, 373+/-48, and 122+/-37 pg/ml ; Group S-ANP : 0, 0, 191+/-68, 261+/-49, 23+/-13, and 0 pg/ml ; TNFalpha : Group ANP : 88+/-42, 371+/-40, 2963+/-291, 276+/-30, 197+/-106, and 23+/-14 U/l ; Group S-ANP : 91+/-34, 41+/-25, 68+/-42, 25+/-9, 0, and 0 U/ml )
Yan et al., J Surg Res 2005
:
The objective of this study was to determine the expression of
somatostatin (SST) and its receptors ( SSTRs ) and their
regulation by
TNF-alpha as well as cell proliferation in response to SST in human endothelial cells ...
TNF-alpha ( 1 ng/ml )
reduced SST , SSTR-1, SSTR-2, and SSTR-5 by 93, 51, 85, and 99 %, respectively, compared to controls ( P < 0.001, t test )
Zhu et al., Zhonghua Yi Xue Za Zhi 2007
(Disease Models, Animal...) :
[ The
effects of
somatostatin on serum interleukin-6 and
tumor necrosis factor-alpha in lipopolysaccharide induced septic shock : experiment with rats ] ... To explore the
effect of
somatostatin on serum interleukin (IL)-6 and
tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS) induced septic shock ...
Somatostatin can
inhibit the level of serum IL-6 and
TNF-alpha in septic shock induced by LPS and improve the survival rate
Beales et al., Gastroenterology 1997
:
The aim of this study was to examine whether IL-8 and
TNF-alpha could
regulate somatostatin release from isolated canine gastric D cells
Hernanz et al., J Neuroimmunol 1996
:
Differential
effects of gastrin releasing peptide, neuropeptide Y,
somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and
tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the
effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ),
somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and
TNF alpha by peripheral whole blood cells from healthy young and old people ... The
TNF alpha production was
stimulated by NPY and
somatostatin in young subjects, and by NPY, somatostatin and VIP in old ones, whereas GRP produced a decrease of TNF alpha in young persons