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IFNGR1 — STAT1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: STAT1 → IFNGR1 (increases, IFNGR1 Activity) Qing et al., J Biol Chem 2005*
  Evidence: Upon stimulation, mouse IFNgamma receptor subunit 1 (IFNGR1) is phosphorylated on several cytoplasmic tyrosine residues, and Tyr(419) is required for signal transducer and activator of transcription (STAT) 1 activation in mouse embryo fibroblasts.
• KEGG Osteoclast differentiation: IFNGR1/IFNGR2 → STAT1 (protein-protein, activation)
• NCI Pathway Database IFN-gamma pathway: IFN-gamma/IFN-gammaR/JAK1/JAK1/JAK2/JAK2 complex (IFNGR1-JAK1-JAK2-IFNG) → STAT1 (STAT1) (modification, activates) Shuai et al., Science 1992*, Igarashi et al., J Biol Chem 1994, Shuai et al., Science 1993, Greenlund et al., EMBO J 1994, Müller et al., Nature 1993
  Evidence: mutant phenotype, assay, physical interaction
• Reactome Reaction: IFNGR1 → STAT1 (indirect_complex) Nair et al., Proc Natl Acad Sci U S A 2002, Aaronson et al., Science 2002, DeVries et al., J Biol Chem 2004, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993, Greenlund et al., Immunity 1995*, Greenlund et al., EMBO J 1994, Briscoe et al., EMBO J 1996
• Reactome Reaction: IFNGR1 → STAT1 (reaction) Aaronson et al., Science 2002, McBride et al., Science's STKE : signal transduction knowledge environment 2003*, Wenta et al., Proc Natl Acad Sci U S A 2008*, Shuai et al., Cell 1994, Quelle et al., J Biol Chem 1995, Shuai et al., Science 1993, Greenlund et al., Immunity 1995*, Greenlund et al., EMBO J 1994, Briscoe et al., EMBO J 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: STAT1 — IFNGR1 (colocalization, imaging technique) Noon-Song et al., Biochem Biophys Res Commun 2011
• IRef Biogrid Interaction: STAT1 — IFNGR1 (physical association, affinity chromatography technology) Pang et al., Mol Cell Biol 2000*
• IRef Dip Interaction: STAT1 — IFNGR1 (physical association, coimmunoprecipitation) Weber-Nordt et al., J Biol Chem 1996*
• IRef Hprd Interaction: STAT1 — IFNGR1 (in vivo) Park et al., J Immunol 2004*, Igarashi et al., J Biol Chem 1994
• IRef Intact Interaction: STAT1 — IFNGR1 (association, x-ray crystallography) Mao et al., Mol Cell 2005*
• IRef Intact Interaction: STAT1 — IFNGR1 (association, coimmunoprecipitation) Greenlund et al., EMBO J 1994
• IRef Intact Interaction: STAT1 — IFNGR1 (association, competition binding) Greenlund et al., EMBO J 1994
• IRef Intact Interaction: STAT1 — IFNGR1 (association, competition binding) Gerhartz et al., J Biol Chem 1996
• IRef Intact Interaction: STAT1 — IFNGR1 (association, electrophoretic mobility shift assay) Gerhartz et al., J Biol Chem 1996
• IRef Intact Interaction: STAT1 — IFNGR1 (association, inferred by author) Hemmann et al., J Biol Chem 1996
• IRef Ophid Interaction: STAT1 — IFNGR1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Takaki et al., Genes Cells 2006 : Thus, multiple mechanisms are present for the TGF-beta1 mediated reduction of iNOS production, and we propose a novel mechanism for regulating inflammatory cytokine by an anti-inflammatory cytokine, TGF-beta1 ; i.e. suppression of IFN-gamma induced STAT1 activation by an association of the IFNGR1 with the TGF-betaRI
Ahmad et al., Osteoarthritis Cartilage 2009 (Osteoarthritis) : Consequently, IFN-gamma stimulated STAT1 phosphorylation mediated by IFN-gammaR1 was also considerably reduced in OA patient chondrocytes