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STAT1 — TRAF6

Pathways - manually collected, often from reviews:

• KEGG Osteoclast differentiation: STAT1 → TRAF2/TRAF6 (protein-protein, inhibition)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 12 proteins (association, anti tag coimmunoprecipitation) Li et al., Immunity 2011

Text-mined interactions from Literome

Ohshima et al., Biochem Biophys Res Commun 2011 : An in silico analysis of transcription factor binding sites in plausible promoter regions of differentially expressed genes suggests that STAT1 is involved in TRAF6- and NIK dependent gene expression
Mangino et al., PloS one 2011 (Inflammation) : Finally silencing experiments in THP-1 monocytic cells indicate that both TRAF2 and, surprisingly, TRAF6 are required for the Nef induced tyrosine phosphorylation of STAT1 and STAT2