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CASP3 — STAT3
Pathways - manually collected, often from reviews:
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OpenBEL Selventa BEL large corpus:
CASP3
→
STAT3
(decreases, STAT3 Activity, CASP3 Activity)
Evidence: Several studies have further suggested that the upregulation of STAT3 directly confers a drug-resistance phenotype. For example, overexpression of this transcription factor protects epidermal keratinocytes or cervical carcinoma cells from ultraviolet radiation (UV)-induced apoptosis [74,75]. In addition, STAT3 deficiency sensitizes keratinocytes to UV-induced apoptosis. Interestingly, a simple application of a naked STAT3 plasmid on the skin is sufficient to prevent the effect of irradiation. Th...
Text-mined interactions from Literome
Adamus et al., J Autoimmun 2003
(Autoimmune Diseases...) :
The present study shows that an AAV mediated delivery of CNTF may protect photoreceptors from antibody induced cell death through the
activation of
STAT3 and the suppression of caspase 3 activity, a key
caspase leading to apoptosis
Frias et al., Cardiovasc Res 2008
:
Depleting
Stat3 expression by 50-60 % in isolated ventricular cardiomyocytes markedly
reduced the protective effect of PGE ( 2 ) on DOX induced
caspase3 activation and DNA fragmentation
Rafei et al., J Immunol 2009
(Encephalomyelitis, Autoimmune, Experimental) :
Treatment of CD4 T cells derived from experimental autoimmune encephalomyelitis mice with GMME1 leads to p38 hyperphosphorylation, inhibition of p44/42, AKT and
STAT3 phosphorylation, and
caspase-3 activation
Jabbour et al., Transplantation 2011
(Myocardial Reperfusion Injury) :
Functional improvements were accompanied by increased phosphorylation of Akt, ERK1/2,
STAT3 , and GSK-3ß and
reduced cleaved
caspase-3 ( P < 0.01 )
Kannaiyan et al., Br J Pharmacol 2011
(Multiple Myeloma) :
Celastrol also inhibited both the constitutive and IL6 induced activation of
STAT3 , which induced apoptosis as indicated by an increase in the accumulation of cells in the sub-G1 phase, an increase in the expression of pro-apoptotic proteins and
activation of
caspase-3
Khan et al., BioMed research international 2013
(Liver Neoplasms) :
This alantolactone induced apoptosis was found to be associated with GSH depletion,
inhibition of
STAT3 activation, ROS generation, mitochondrial transmembrane potential dissipation, and increased Bax/Bcl-2 ratio and
caspase-3 activation