Gene interactions and pathways from curated databases and text-mining

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CREBBP — STAT5A

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: Complex of CREBBP-STAT5A (increases) Gewinner et al., J Biol Chem 2004*
    Evidence: This modification was only found on nuclear Stat5 after cytokine activation Only the glycosylated form of Stat5 was able to bind the coactivator of transcription CBP
  • OpenBEL Selventa BEL large corpus: STAT5A → Complex of CREBBP-STAT5A (directlyIncreases, CREBBP/STAT5A Activity) Gewinner et al., J Biol Chem 2004*
    Evidence: This modification was only found on nuclear Stat5 after cytokine activation Only the glycosylated form of Stat5 was able to bind the coactivator of transcription CBP
  • BioCarta il-7 signal transduction: Nmi/p300/CBP complex (NMI-EP300-CREBBP) → STAT5/STAT5/Nmi/p300/CBP complex (STAT5A_STAT5B-NMI-EP300-CREBBP) (modification, collaborate)
  • BioCarta il-7 signal transduction: Nmi/p300/CBP complex (NMI-EP300-CREBBP) → STAT5/STAT5 complex (STAT5A_STAT5B) (modification, collaborate)
  • BioCarta il-7 signal transduction: STAT5/STAT5/Nmi/p300/CBP complex (STAT5A_STAT5B-NMI-EP300-CREBBP) → STAT5/STAT5 complex (STAT5A_STAT5B) (modification, collaborate)
  • KEGG Jak-STAT signaling pathway: CREBBP/EP300 → STAT1/STAT2/STAT3/STAT4/STAT5A/STAT5B/STAT6 (protein-protein, binding/association)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *