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ESR1 — STAT5A
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind_translation Interaction:
STAT5A
—
ESR1
(affinity chromatography technology)
Wang et al., FEBS Lett 2004*
-
IRef Bind_translation Interaction:
STAT5A
—
ESR1
(coimmunoprecipitation)
Wang et al., FEBS Lett 2004*
-
IRef Bind_translation Interaction:
STAT5A
—
ESR1
(experimental interaction detection)
Wang et al., FEBS Lett 2004*
-
IRef Biogrid Interaction:
STAT5A
—
ESR1
(physical association, affinity chromatography technology)
Wang et al., FEBS Lett 2004*
-
IRef Biogrid Interaction:
STAT5A
—
ESR1
(direct interaction, pull down)
Faulds et al., Mol Endocrinol 2001*
-
IRef Hprd Interaction:
STAT5A
—
ESR1
(in vivo)
Wang et al., FEBS Lett 2004*
-
IRef Hprd Interaction:
STAT5A
—
ESR1
(in vitro)
Wang et al., FEBS Lett 2004*
-
IRef Intact Interaction:
STAT5A
—
ESR1
(physical association, pull down)
Wang et al., FEBS Lett 2004*
-
IRef Intact Interaction:
STAT5A
—
ESR1
(physical association, coimmunoprecipitation)
Wang et al., FEBS Lett 2004*
-
IRef Ophid Interaction:
STAT5A
—
ESR1
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Stoecklin et al., J Steroid Biochem Mol Biol 1999
:
The
estrogen receptor diminishes
Stat5 mediated induction and the androgen receptor has no effect ... Conversely,
Stat5 negatively interferes with glucocorticoid receptor, mineralocorticoid receptor and progesterone receptor induced transcription from the MMTV LTR and the
estrogen receptor induced transcription from an ERE containing promoter
Frasor et al., Mol Endocrinol 2001
:
Interestingly, either
Stat5a or Stat5b could
stimulate ERalpha transcription while stimulation of ERbeta occurred only in the presence of Stat5b ... These findings indicate that PRL stimulation of ER expression occurs at the level of transcription and that PRL regulation of
ERalpha can be
mediated by either
Stat5a or Stat5b, while regulation of ERbeta appears to be mediated only by Stat5b
Yamashita et al., Oncogene 2003
:
Cotransfection experiments revealed that
Stat5aDelta740 completely
blocked transcriptional activity of endogenous estrogen receptor in T47D and MCF7 cells, and of both
ER alpha and ER beta in COS-7 cells ... Cotransfection experiments revealed that
Stat5aDelta740 completely
blocked transcriptional activity of endogenous
estrogen receptor in T47D and MCF7 cells, and of both ER alpha and ER beta in COS-7 cells
Frasor et al., Trends Endocrinol Metab 2003
:
A single nucleotide difference between these two response elements is responsible for the observation that either
Stat5a or Stat5b can
stimulate Esr1 transcription, whereas only Stat5b can activate transcription of Esr2
Boerner et al., Mol Endocrinol 2005
(Breast Neoplasms) :
ERalpha transcriptional activity was not
necessary for suppression of
STAT5 activity ... However,
ERalpha did
prevent basal increases in
STAT5 activity with overexpressed c-Src