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CDC37 — STK11

Pathways - manually collected, often from reviews:

• NCI Pathway Database LKB1 signaling events: CDC37 (CDC37) → LKB1/CDC37/HSP90 complex (STK11-CDC37-HSP90AA1) (modification, collaborate)
  Boudeau et al., Biochem J 2003*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: CDC37 (CDC37) → LKB1 (STK11) (modification, collaborate) Boudeau et al., Biochem J 2003*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: LKB1/CDC37/HSP90 complex (STK11-CDC37-HSP90AA1) → Hsp90 (HSP90AA1) (modification, collaborate) Boudeau et al., Biochem J 2003*
  Evidence: physical interaction
• NCI Pathway Database LKB1 signaling events: LKB1/CDC37/HSP90 complex (STK11-CDC37-HSP90AA1) → LKB1 (STK11) (modification, collaborate) Boudeau et al., Biochem J 2003*
  Evidence: physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: Complex of 15 proteins Brajenovic et al., J Biol Chem 2004
• IRef Biogrid Interaction: CDC37 — STK11 (physical association, affinity chromatography technology) Gaude et al., Oncogene 2012*
• IRef Biogrid Interaction: CDC37 — STK11 (physical association, affinity chromatography technology) Boudeau et al., Biochem J 2003*
• IRef Biogrid Interaction: CDC37 — STK11 (direct interaction, pull down) Boudeau et al., Biochem J 2003*
• IRef Biogrid Interaction: CDC37 — STK11 (physical association, affinity chromatography technology) Behrends et al., Nature 2010
• IRef Biogrid Interaction: CDC37 — STK11 (physical association, affinity chromatography technology) Nony et al., Oncogene 2003*
• IRef Biogrid Interaction: CDC37 — STK11 (physical association, affinity chromatography technology) Brajenovic et al., J Biol Chem 2004
• IRef Intact Interaction: Complex of FKBP5-STRADA-CAB39-STK11-STK11-CAB39L-STRADB-CDC37 (physical association, anti tag coimmunoprecipitation) Behrends et al., Nature 2010
• IRef Intact Interaction: Complex of 15 proteins (association, anti tag coimmunoprecipitation) Brajenovic et al., J Biol Chem 2004
• IRef Ophid Interaction: CDC37 — STK11 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CDC37 — STK11 (aggregation, confirmational text mining) Boudeau et al., Biochem J 2003*

Text-mined interactions from Literome

Nony et al., Oncogene 2003 (Peutz-Jeghers Syndrome...) : Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37
Wu et al., EMBO J 1997 : Cdc2/Cdc13 activity is also indirectly regulated by the approximately 70 kDa Nim1 ( Cdrl ) serine/threonine kinase , which promotes mitosis by inhibiting Wee1 via direct phosphorylation