Huang et al., Cell Death Differ 2006
:
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL
Besse et al., J Biol Chem 2007
:
Furthermore, TAK1-C100 blocked RANKL induced nuclear accumulation of NFATc1 and consequently osteoclast differentiation consistent with the ability of a catalytically inactive TAK1 to block RANKL mediated signaling