Gene interactions and pathways from curated databases and text-mining

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IRF6 — TCF15

Text-mined interactions from Literome

Steer et al., J Biol Chem 2000 : LPS increased nuclear c-Jun/ATF-2, NF-kappaB ( 1 ) /Rel-A, and Rel-A/C-Rel transcription factor complexes, which bound specifically to oligonucleotide sequences from the -106 to -88 base pair ( bp ) region of the promoter
Medvedev et al., J Immunol 2000 (MAP Kinase Signaling System) : In this study, the effect of in vitro endotoxin tolerance on LPS induced mitogen activated protein kinase activation, transcription factor induction , and cytokine, chemokine, and Toll-like receptor (TLR) 2 and 4 gene expression, as well as the involvement of TNF and IL-1 signaling pathways in tolerance, were examined
Heiss et al., J Biol Chem 2001 : Consequently, nuclear factor kappa B (NF-kappa B), a pivotal transcription factor in LPS stimulated pro-inflammatory response, was identified as the key mediator
Hullinger et al., J Biol Chem 2001 : 5'-Deletion analysis and gel shift data suggest that LPS inhibits binding of a novel transcription factor to a myeloid zing finger protein-1-like element ( -476 to -456 ) in the human SR-BI promoter
You et al., Biochem Biophys Res Commun 2002 : Transient expression and electrophoretic mobility shift assays with NF-kappaB binding sites revealed that NP reduced the levels of the LPS induced NF-kappaB transcription factor complex
Gordon et al., J Immunol 2003 : We have found that the binding of the transcription factor , Yin Yang 1 (YY1), to hs3 and to the mu E1 site of the intronic enhancer, E mu, is induced in primary splenic B cells after approximately 48 h in response to LPS and other activators of class switch recombination
Kim et al., Cancer Lett 2003 : Transient expression and electrophoretic mobility shift assays with NF-kappaB binding sites revealed that BPA reduced the levels of the LPS induced NF-kappaB transcription factor complex
Sarkar et al., FEBS Lett 2003 (Inflammation) : alpha-MSH also inhibited SA-LPS induced nuclear transcription factor kappaB activation not only in macrophages, but also in a T-cell line and human neutrophils isolated from fresh blood
Tang et al., Proc Natl Acad Sci U S A 2005 : LPS induces the interaction of a transcription factor , LPS induced TNF-alpha factor, and STAT6 ( B ) with effects on multiple cytokines
Equils et al., Clin Exp Immunol 2006 : Here we show that 1,25- ( OH ) 2 D3 pretreatment of human microvessel endothelial cells ( HMEC ) inhibited the enteric gram negative bacterial lipopolysaccharide (LPS) activation of transcription factor NF-kappaB and interleukin (IL)-6, IL-8 and regulated upon activation normal T cell exposed and secreted ( RANTES ) release
Djoko et al., J Agric Food Chem 2007 (Inflammation) : In further, when these stilbenoids were subjected to monitoring their inhibitory effectiveness on LPS induced transcription factor expressions of C/EBPdelta and C/EBPbeta, only C/EBPdelta expressions were reduced
Shembade et al., EMBO J 2007 : The NF-kappaB transcription factor is normally transiently activated by proinflammatory cytokines and bacterial lipopolysaccharide (LPS) ; however, persistent NF-kappaB activation is commonly observed in inflammatory disease and malignancy
Uchida et al., J Surg Res 2008 (Disease Models, Animal...) : NE inhibitor prevented the activation of the transcription factor , nuclear factor-kappa B, induced by GalN/LPS
Aoki et al., Biol Pharm Bull 2008 : To determine the role of nitric oxide ( NO ) in rat liver transporter regulation, we investigated whether NO mediates lipopolysaccharide (LPS) induced changes in transporters and their transcription factor expression using aminoguanidine ( AG ), an inhibitor of induced nitric oxide synthase (iNOS)
Radnai et al., J Nutr 2009 (Inflammation) : Additionally, FA inhibited LPS induced activation of nuclear factor kappaB transcription factor in the liver of the mice
Chang et al., J Pharmacol Sci 2009 : Furthermore, the LPS induced degradation of cytosolic IkappaB-alpha and activation of nuclear transcription factor-kappaB ( NF-kappaB ) were also inhibited by FC-77
Haschemi et al., PloS one 2011 (Inflammation) : Previously, we demonstrated that CO inhibits lipopolysaccharide (LPS) induced expression of the proinflammatory early growth response-1 (Egr-1) transcription factor in macrophages via activation of PPAR?
Vilekar et al., Int Immunol 2012 : These effects were accompanied by the inhibition of LPS induced activation of transcription factor nuclear factor kappa-light-chain enhancer of activated B cells ( NF-?B )
Li et al., Inflamm Res 2013 (Mastitis) : Further studies revealed that salidroside down-regulated phosphorylation of LPS induced nuclear transcription factor-kappaB ( NF-?B ) p65 and inhibitor of NF-?B a ( I?Ba ) in the NF-?B signal pathway, and suppressed phosphorylation of p38, extracellular signal regulated kinase ( ERK ) and c-jun NH ( 2 ) -terminal kinase ( JNK ) in MAPKs signal pathways
Smith et al., PLoS Pathog 2012 (Malaria) : Here we report on the involvement of the Anopheles gambiae orthologue of a conserved component of the vertebrate immune system, LPS induced TNFa transcription factor ( LITAF ), and its role in mosquito anti-Plasmodium immunity
Wu et al., Int J Immunopathol Pharmacol 2012 (Liver Failure, Acute) : In addition, pretreatment mice with PD dose-dependently suppressed tumor necrosis factor-alpha (TNF-alpha) production, myeloperoxidase (MPO) activity, intercellular adhesion molecule-1 ( ICAM-1 ) and endothelial cell adhesion molecule-1 ( ECAM-1 ) expression, caspase-3 activation, and transcription factor nuclear factor-kappa B(NF-kB) activity induced by LPS
Büscher et al., Mol Cell Biol 1995 : Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors ( TCFs ), TCF/Elk and TCF/SAP
Hu et al., J Biol Chem 1998 : To ascertain how P2Z/P2X7 receptor antagonists influence LPS signaling, we evaluated the capacity of o-ATP to regulate LPS mediated activation of the transcription factor , nuclear factor-kappaB, and the mitogen activated protein kinases, extracellular signal regulated kinase ( ERK ) 1 and ERK2
Rescigno et al., J Exp Med 1998 : We found that LPS induced nuclear translocation of the nuclear factor (NF)-kappaB transcription factor