Gene interactions and pathways from curated databases and text-mining

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SHH — TCF23

Text-mined interactions from Literome

Chen et al., Development 2004 (Polydactyly) : Shh regulates digit formation largely by preventing cleavage of the Gli3 transcription factor to a repressor form that shuts off expression of Shh target genes
Colvin Wanshura et al., Cancer Res 2011 (Cell Transformation, Neoplastic...) : We report that the transcription factor and oncogene Snail1 ( Sna1 ) is directly induced by Shh pathway activity in GCPs, murine medulloblastomas, and human medulloblastoma cells
Harris et al., Oncogene 2012 (Breast Neoplasms...) : In these cells, SHH caused activation of the Hh transcription factor , GLI1, leading to upregulated expression of the potent pro-angiogenic secreted molecule, CYR61 ( cysteine-rich angiogenic inducer 61 )
Tanabe et al., Cell 1998 : Our results suggest that the Shh mediated induction of a single transcription factor , MNR2, is sufficient to direct somatic motor neuron differentiation