Sumi et al., Yakugaku Zasshi 2007
:
Although IKKbeta activates transcription factor NF-kappaB and PTP1B negatively regulates the receptor-protein tyrosine kinase , such as epidermal growth factor receptor (EGFR) in cells, covalent modification of these proteins caused by 1,2-NQ results in inhibition of NF-kappaB activity and transactivation of EGFR
Palka-Hamblin et al., J Cell Sci 2010
:
In the SW620 colorectal adenocarcinoma cell line, nuclear targeted PTK6 negatively regulates endogenous beta-catenin/TCF transcriptional activity, whereas membrane targeted PTK6 enhances beta-catenin/TCF regulated transcription
Brauer et al., PloS one 2011
(Colonic Neoplasms...) :
While ALT-PTK6 alone did not influence ß-catenin/TCF transcriptional activity in a luciferase reporter assay, it enhanced PTK6 mediated inhibition of ß-catenin/TCF transcription by promoting PTK6 nuclear functions