Gene interactions and pathways from curated databases and text-mining

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PSEN1 — TCF4

Text-mined interactions from Literome

Teo et al., Proc Natl Acad Sci U S A 2005 : A familial Alzheimer 's disease associated PS-1 mutant, PS-1 ( L286V ), causes a dramatic increase in T cell factor ( TCF ) /beta-catenin transcription in PC-12 cells, which prevents normal nerve growth factor (NGF) induced neuronal differentiation and neurite outgrowth
Raurell et al., PloS one 2008 (Alzheimer Disease) : Gamma-secretase dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity