Mikasa et al., J Bone Miner Metab 2011
:
Runx2 induced Tcf7 and Lef1 strongly, but Tcf7l1 and Tcf7l2 only slightly in Runx2 ( -/- ) chondrocytes ; the expressions of Tcf7 and Tcf7l2 were reduced in Runx2 ( -/- ) cartilaginous skeletons and calvaria, and Tcf7 showed a similar expression pattern to Runx2
Cristancho et al., Proc Natl Acad Sci U S A 2011
:
Depletion of TCF7L1 inhibits differentiation, because TCF7L1 indirectly induces the adipogenic transcription factor peroxisome proliferator activated receptor ? in a manner that can be replaced by inhibition of myosin II activity