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CRK — TGFB1
Text-mined interactions from Literome
Park et al., Hepatology 2002
(Carcinoma, Hepatocellular...) :
Inhibition of ERK activity enhanced
TGF-beta1 induced
p38 and JNK activation
Hyman et al., Surgery 2002
(MAP Kinase Signaling System) :
TGF-beta1 induced
p38 ( MAPK ), extracellular signal regulated kinase 1/2, and c-Jun N-terminal kinase 1/2 activation and increased apoptosis
Dai et al., J Biol Chem 2003
:
Both Smad-2 and
p38 mitogen activated protein ( MAP ) kinase were rapidly
activated by
TGF-beta1 , as demonstrated by the early induction of phosphorylated Smad-2 and p38 MAP kinase, respectively
Edlund et al., Mol Biol Cell 2003
(Prostatic Neoplasms) :
Ectopic expression of wild-type TAK1 promoted TGF-beta1 induced phosphorylation of p38 and apoptosis, whereas dominant negative TAK1 reduced
TGF-beta1 induced phosphorylation of
p38 and apoptosis
Daian et al., J Invest Dermatol 2003
(Keloid) :
Insulin-like growth factor-I markedly enhanced
transforming growth factor-beta induced phosphorylation of
p38 mitogen activated protein kinase and activating transcription factor-2
Park et al., Oncogene 2004
:
In contrast, overexpression of constitutively active c-Src inhibited apoptosis suppressing
TGF-beta1 induced activation of
p38 , JNK and caspases
Suzuki et al., Clin Exp Nephrol 2004
:
NRK fibroblasts exposed to high glucose demonstrated increased
TGF-beta1 induced
p38 MAP kinase activation
Kim et al., Invest Ophthalmol Vis Sci 2005
:
TGF-beta1 also
induced activation of Smad2, JNK1/2, ERK1/2, and
p38 within 5 to 15 minutes, with peak activation at 15 to 60 minutes
Guo et al., World J Gastroenterol 2005
:
To investigate the differential phosphorylation and
activation of
p38 in hepatocytes by pro-apoptotic
Transforming Growth Factor-beta1 ( TGF-beta1 ), pro-survival factors Epidermal Growth Factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) and the potential mechanisms ... The results showed SB202190 had no effect on
TGF-beta1 induced phosphorylation of
p38 , but effectively inhibited both EGF and TPA induced phosphorylation of p38
Ferrari et al., Proc Natl Acad Sci U S A 2006
:
Inhibition of p38 ( MAPK ) blocks TGF-beta1 induced apoptosis, showing that VEGF/flk-1 mediated activation of
p38 ( MAPK ) is
required for
TGF-beta1 induction of apoptosis
Kim et al., American journal of physiology. Renal physiology 2007
:
TGF-beta activated kinase 1 and TAK1 binding protein 1 cooperate to mediate
TGF-beta1 induced
MKK3-p38 MAPK activation and stimulation of type I collagen
Sadej et al., Cancer Res 2010
(Breast Neoplasms...) :
We also found that CD151 regulates the compartmentalization of TGF-beta type I receptor ( TbetaRI/ALK-5 ) and specifically controls the
TGFbeta1 induced activation of
p38