◀ Back to TGFB1
TGFB1 — TGFBI
Text-mined interactions from Literome
Dieudonné et al., J Cell Biochem 1999
:
Seven clones were isolated and characterized by DNA sequencing and found to encode the following genes :
transforming growth factor-beta induced gene product ( (
beta)ig-h3) , calphobindin II, cytosolic thyroid binding protein, 22-kDA smooth muscle protein ( SM22 ), and the extracellular matrix proteins osteonectin/SPARC, type III collagen, and fibronectin
Fujiki et al., Cornea 2000
(Corneal Dystrophies, Hereditary) :
To investigate mutations of the human transforming growth factor beta induced gene ( TGFBI ),
transforming growth factor-beta induced gene product (
betaig-h3 , keratoepithelin ), in Japanese patients with Avellino corneal dystrophy (ACD), lattice corneal dystrophy ( LCD ), granular corneal dystrophy (GCD), and Reis-Bücklers corneal dystrophy ( RBCD )
Sasaki et al., Am J Obstet Gynecol 2002
(Pre-Eclampsia) :
Periostin has high amino acid homology with
transforming growth factor-beta induced protein
beta igh3 , a molecule induced by transforming growth factor-beta(1), which promotes the adhesion and spreading of fibroblasts
Schneider et al., Biochim Biophys Acta 2002
(Pancreatic Neoplasms) :
In this report, we determined that
betaig-h3 mRNA levels were
induced by
TGF-beta1 in two out of five examined pancreatic cancer cell lines ( CAPAN-1, PANC-1 ) ... In CAPAN-1 cells, which harbor a Smad4 mutation,
betaig-h3 but not PAI-1 was
induced by
TGF-beta1 , whereas in PANC-1 cells that express wild-type Smad4, TGF-beta1 induced both PAI-1 and betaig-h3
Yun et al., Brain Res Mol Brain Res 2002
(Brain Injuries...) :
Induction of
TGF-beta-inducible gene-h3 (betaig-h3) by
TGF-beta1 in astrocytes : implications for astrocyte response to brain injury ... The aims of this study were to determine the
effect of
TGF-beta1 on
betaig-h3 expression in cultured astrocytes and to examine whether betaig-h3 is expressed in the brain after traumatic injury
Kim et al., Neurosci Lett 2003
(Astrocytoma) :
We have recently found that
beta(ig)-h3 expression is
induced in cultured astrocytes by
TGF-beta1 and in rat cerebral cortex by stab wound
Wang et al., Ophthalmic Genet 2002
:
To determine the
roles of
transforming growth factor-beta( 1) ( TGF-beta(1) ), epidermal growth factor (EGF), and cell density on the regulation of the
TGFBI gene transcript in a human corneal epithelial cell line ( HCE-T ) ...
TGF-beta(1) upregulates
TGFBI gene transcript in this human corneal epithelial cell line, reaching a peak of 2.5-fold of upregulation at 48 h after TGF-beta(1) treatment and a 1.5-fold at 72 h
Jeong et al., J Cell Biochem 2004
:
TGF-beta1 did not increase the amount of the alpha3beta1 integrin on the cell surface, but rather
increased its affinity for
betaig-h3
Park et al., Exp Mol Med 2004
:
RPTEC constitutively expressed
betaig-h3 and the expression was dramatically
induced by exogenous
TGF-Beta1 treatment
Atchaneeyasakul et al., Jpn J Ophthalmol 2006
(Corneal Dystrophies, Hereditary...) :
To describe a large Thai family with lattice corneal dystrophy ( LCD ) type I and to determine whether this LCD is associated with mutations within the
transforming growth factor-beta induced (
TGFBI ) gene
Park et al., Nephrol Dial Transplant 2008
:
In vitro,
TGF-beta1 induced
betaig-h3 in cultured HPMCs, and betaig-h3 mediated mesothelial cell adhesion occurred via alphavbeta3 integrin
Kobayashi et al., Arch Ophthalmol 2007
(Corneal Dystrophies, Hereditary) :
In Avellino corneal dystrophy ( Arg124His mutation of human
transforming growth factor beta induced gene
[TGFBI ] ), highly reflective granular materials with irregular edges were observed in the superficial stroma
Afshari et al., Molecular vision 2008
(Corneal Dystrophies, Hereditary) :
To evaluate the
TGFBI gene and the encoded
transforming growth factor beta induced protein ( TGFBIp ) in a 47-year-old African-American patient with an unusual atypical asymmetric lattice corneal dystrophy ( LCD )
Wheeldon et al., Molecular vision 2008
(Corneal Dystrophies, Hereditary) :
Corneal dystrophy of Bowman 's layer ( CDB ) belongs to a group of dystrophies associated with mutations in the
transforming growth factor-beta induced (
TGFBI ) gene
Tai et al., Cornea 2009
(Keratoconus) :
The excised corneal buttons from 2 patients diagnosed clinically with keratoconus underwent histochemical analysis with Masson trichrome, Congo red, Alcian blue, and periodic acid-Schiff stains, and immunohistochemical analysis for the
transforming growth factor beta induced gene (
TGFBI ) protein product ( TGFBIp ), prealbumin, lysozyme, and kappa and lambda light chain expression
Seo et al., Am J Nephrol 2009
(Diabetes Mellitus, Experimental...) :
PAI-1 deficiency also reduced HG-induced
betaig-h3 , a
TGF-beta1 induced gene product, mRNA expression
Zhang et al., Molecular vision 2011
(Corneal Dystrophies, Hereditary) :
To identify clinical features and mutations within the
transforming growth factor-beta induced (
TGFBI ) gene in three Chinese families with Granular corneal dystrophy, type 1 ( GCD1 ) and Granular corneal dystrophy, type 2 ( GCD2 )
Gilbert et al., Kidney Int 1998
(Diabetes Mellitus, Experimental) :
The
effect of exogenous
TGF-beta1 on
beta ig-h3 expression was also assessed in cultured proximal tubular cells