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AHSA1 — TLR4

Text-mined interactions from Literome

Dubourdeau et al., J Immunol 2006 (MAP Kinase Signaling System) : Our investigations revealed that immunocompetent TLR2, TLR4 , and MyD88 knockout mice were not more susceptible to invasive aspergillosis as compared with wild-type mice and that the in vitro phosphorylation of the MAPKs ERK and p38 was not affected in TLR2, TLR4, or MyD88 knockout mice following stimulation with conidia
Kawakami et al., J Rheumatol 2007 (Sjogren's Syndrome) : TLR ligands induced phosphorylation of ERK, JNK, and p38 in HSG cells, but not Akt phosphorylation or activation of NF-kappaB p65
Michelsen et al., Atherosclerosis 2010 (Carotid Artery Diseases...) : Our main findings were : ( 1 ) serum YKL-40 levels were significantly elevated in patients with carotid atherosclerosis, with particularly high levels in those with symptomatic disease ; ( 2 ) patients with recent ischemic symptoms ( within 2 months ) had higher YKL-40 mRNA levels in carotid plaque than other patients ; ( 3 ) in vitro, the beta-adrenergic receptor agonist isoproterenol, toll-like receptor (TLR) 2 and TLR4 agonists, and in particular releasate from activated platelets significantly increased the expression of YKL-40 in THP-1 monocytes and ( 4 ) in vitro, YKL-40 increased matrix metalloproteinase-9 expression and activity in THP-1 monocytes, involving activation of p38 mitogen activated protein kinase
Barona et al., J Pharm Pharmacol 2011 : Polymyxin ( TLR4 inhibitor ), SB203580 ( p38 MAPK inhibitor ), SP600125 ( JNK1/2 inhibitor ) and U0126 ( MEK1/2 inhibitor ) antagonized the effects of the LPS on ACh induced contractions in duodenal smooth muscle