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F2RL1 — TLR4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Chung et al., Immunol Lett 2010
(Bacteroidaceae Infections...) :
PAR1 or
PAR2 knock-down
resulted in up-regulated NOD1 and NOD2 expression with P. gingivalis or F. nucleatum stimulation ( p < 0.01 ), as well as enhanced TLR2 and
TLR4 expression when cells were stimulated by bacteria that utilize TLR2 or TLR4, respectively
Nhu et al., Innate Immun 2012
:
In this study, the
effect of
PAR(2) activation on LPS induced
TLR4 signaling was examined in primary murine macrophages
Arizmendi et al., J Immunol 2011
(Bronchial Hyperreactivity...) :
PAR(2) activation by CE
acts as an adjuvant for allergic sensitization even in the absence of functional
TLR4
Williams et al., Journal of signal transduction 2011
:
Our results support the notion that
PAR-2 plays a role in LPS activation of
TLR4 signaling in macrophages