◀ Back to TLR8
TLR7 — TLR8
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
TLR8
→
TLR7
(reaction)
Li et al., Proc Natl Acad Sci U S A 2002, Kollewe et al., J Biol Chem 2004, Kawai et al., Nat Immunol 2004, Cheng et al., Biochem Biophys Res Commun 2007, Kawagoe et al., J Exp Med 2007, Kawagoe et al., Nat Immunol 2008, Ning et al., Mol Cell Biol 2008
Text-mined interactions from Literome
Wang et al., J Biol Chem 2006
(Inflammation) :
The results indicate that
TLR8 inhibits
TLR7 and TLR9, and TLR9 inhibits TLR7 but not vice versa in HEK293 cells transfected with TLRs in a pairwise combination ... The murine
TLR8 that does not respond to any known human TLR8 agonists also
inhibits both murine and human
TLR7
Sel et al., J Immunol 2007
(Asthma...) :
These data indicate that TLR-3 or
TLR-7 activation by viral
TLR ligands has both preventive as well as suppressive effects on experimental asthma which is mediated by the additive effects of IL-12 and IL-10
Hamm et al., J Immunotoxicol 2009
(Lung Neoplasms) :
TLR7 expression on antigen presenting cells is
detected in plasmacytoid dendritic cells, CD34+ derived dendritic cells, and B-cells, whereas
TLR8 is mainly expressed on cells of the myeloid lineage, such as monocytes, macrophages, and myeloid dendritic cells
Kwissa et al., Blood 2012
:
In the draining lymph nodes ( LNs ), consistent with the effects in blood, all
TLR-Ls induced expansion of CD14 ( + ) monocytes, but only
TLR7/8-L and TLR9-L expanded the activated CD14 ( + ) CD16 ( + ) cells
Ciechomska et al., Ann Rheum Dis 2013
(Arthritis, Rheumatoid...) :
This study demonstrates profibrotic properties of circulating monocytes from patients with SSc and a key
role for
TLR signalling, particularly
TLR8 , in TIMP-1 secretion and matrix remodelling
Römmler et al., J Immunol 2013
:
Whereas TLR9 induced TNF-a secretion of bone marrow derived macrophages and conventional dendritic cells was equally inhibited by INH-ODN 2088 and G-modified INH-ODNs such as INH-ODN 24888,
TLR7 induced TNF-a release and
TLR7- and TLR9 induced IL-12p40 release were significantly more impaired by G-modified INH-ODNs