Scheuner et al., J Biol Chem 2006
:
TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR
Bennett et al., Blood 2006
(Inflammation...) :
Thus, knock-down of RAX expression by 80 % using small interfering RNA ( siRNA ) prevents IFNgamma/tumor necrosis factor alpha (TNFalpha) induced PKR activation and eIF2alpha phosphorylation, IkappaB degradation, IRF-1 expression, and STAT1 phosphorylation, resulting in enhanced murine embryonic fibroblast (MEF) cell survival
Hu et al., Am J Physiol Gastrointest Liver Physiol 2010
:
The IFN-gamma and TNF-alpha effects in upregulation of stress granule formation and downregulation of Hsp70 were eIF-2alpha dependent , and the effect could be negated by blocking eIF-2alpha phosphorylation with use of an RNA dependent protein kinase inhibitor