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FOXO1 — TNFSF10
Text-mined interactions from Literome
Modur et al., J Biol Chem 2002
(Neoplasm Metastasis...) :
These findings suggest that the decreased activity of FKHRL1 and
FKHR in prostate cancers resulting from loss of PTEN
leads to a decrease in
TRAIL expression that may contribute to increased survival of the tumor cells
Park et al., Cell Signal 2009
:
In this study, we found that
TRAIL inhibited PI3K/Akt dependent
FoxO phosphorylation and relocated FoxO proteins into the nucleus from the cytosol in activated human hepatic stellate LX-2 cells ... Collectively, our data suggest that sequential
activation of
FoxO proteins under conditions of suppressed PI3K/Akt signaling by
TRAIL can down-regulate c-FLIP ( L/S ), consequently promoting TRAIL induced apoptosis in LX-2 cells
Chen et al., PloS one 2010
(Prostatic Neoplasms) :
The inhibition of PI3K/AKT pathway
induced FOXO transcriptional activity resulting in induction of Bim,
TRAIL , p27/KIP1, DR4 and DR5, and inhibition of cyclin D1
Keniry et al., Genes Dev 2013
(Breast Neoplasms) :
To gain insight into how FOXOs select specific genes for regulation, we performed a screen for genes that modify
FOXO activation of
TRAIL , a death receptor ligand capable of inducing extrinsic apoptosis