◀ Back to IRF3
IRF3 — TNFSF10
Text-mined interactions from Literome
Kirshner et al., J Virol 2005
:
We show that
IRF-3 is
involved in the transcriptional induction of
TRAIL , a key player in the apoptosis pathway ...
IRF-3 upregulates
TRAIL transcription following viral infection and binds an interferon stimulated response element in the TRAIL promoter
Peters et al., J Virol 2008
(Respirovirus Infections) :
In contrast, IRF-3 activation was essential, although
induction of the proapototic
protein TRAIL by
IRF-3 was not required
Tsuno et al., J Immunother 2009
(Adenocarcinoma...) :
In IFN-alpha treated OVCAR3 cells,
IRF9-RNAi inhibited transcription of
TRAIL whereas Stat1-RNAi did not, suggesting that the transcription of TRAIL induced by IFN-alpha predominantly required IRF9