Gene interactions and pathways from curated databases and text-mining

◀ Back to IRF3

IRF3 — TNFSF10

Text-mined interactions from Literome

Kirshner et al., J Virol 2005 : We show that IRF-3 is involved in the transcriptional induction of TRAIL , a key player in the apoptosis pathway ... IRF-3 upregulates TRAIL transcription following viral infection and binds an interferon stimulated response element in the TRAIL promoter
Peters et al., J Virol 2008 (Respirovirus Infections) : In contrast, IRF-3 activation was essential, although induction of the proapototic protein TRAIL by IRF-3 was not required
Tsuno et al., J Immunother 2009 (Adenocarcinoma...) : In IFN-alpha treated OVCAR3 cells, IRF9-RNAi inhibited transcription of TRAIL whereas Stat1-RNAi did not, suggesting that the transcription of TRAIL induced by IFN-alpha predominantly required IRF9