Gene interactions and pathways from curated databases and text-mining

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PARP15 — TNFSF10

Text-mined interactions from Literome

Guo et al., Blood 2002 : While it had no activity alone, ectopic overexpression of Smac/DIABLO or treatment with the N-terminus heptapeptide ( Smac-7 ) or tetrapeptide ( Smac-4 ) of Smac/DIABLO significantly increased Epo B- or Apo-2L/TRAIL induced processing and PARP cleavage activity of caspase-3
Kouhara et al., Int J Oncol 2007 (Colonic Neoplasms) : Fenretinide and TRAIL cooperatively activated caspase-3, -8, -10 and -9 and cleavage of Bid and PARP , and this activation was also blocked in the presence of DR5/Fc chimeric protein
Moon et al., Toxicol In Vitro 2013 : We first found that VA induces a major molecule of ER stress, CCAAT/enhancer binding protein homologous protein ( CHOP ) -dependent DR5 induction and subsequently increases TRAIL induced cleavage of caspases and PARP in TRAIL-resistant Hep3B cells