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TLR4 — TOLLIP
Pathways - manually collected, often from reviews:
-
BioCarta toll-like receptor pathway:
CD14
→
LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
CD14
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
None
→
LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
None
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta toll-like receptor pathway:
LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96)
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14)
→
CD14/LBP complex (CD14-EHHADH)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14)
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
None
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
CD14/LBP complex (CD14-EHHADH)
→
TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2 complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2)
(modification, collaborate)
-
BioCarta inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages:
LPS/TLR4/TLR4/TIRAP/TOLLIP/MYD88/IRAK/PKR/MD-2/CD14/LBP complex (IRAK1-LY96-TIRAP-TLR4-TOLLIP-MYD88-EIF2AK2-EHHADH-CD14)
(ceramide biosynthetic process, activates)
-
BioCarta toll-like receptor pathway:
LPS/TLR4/TLR4/TIRAP/TOLLIP/PKR/MYD88/IRAK/MD-2/CD14 complex (EIF2AK2-MYD88-CD14-TLR4-TOLLIP-TIRAP-IRAK1-LY96)
→
TRAF6
(modification, activates)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Zhang et al., J Biol Chem 2002
:
Negative
regulation of
TLR signaling by
Tollip may therefore serve to limit the production of proinflammatory mediators during inflammation and infection
Li et al., Mol Immunol 2004
:
Our study provides yet another mechanism for suppressing excessive
TLR signaling activation
mediated by
Tollip
Zhang et al., Infect Immun 2005
(Pseudomonas Infections) :
We also determined that MyD88, IRAK, TRAF6, and
Toll interacting protein (Tollip) , but not TIRAP, were involved in the
TLR mediated response to P. aeruginosa in HAECs
Hong Byun et al., J Immunol 2010
:
Interestingly, EGCG induced a rapid upregulation of
Toll interacting protein (Tollip) , a negative
regulator of
TLR signaling, and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment ... RNA interference mediated silencing of
Tollip impaired the
TLR4 signaling inhibitory activity of EGCG
Byun et al., FEBS Lett 2011
(MAP Kinase Signaling System) :
Silencing of
Toll interacting protein (Tollip) , a negative
regulator of
TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip
Shah et al., J Immunol 2012
(Genetic Predisposition to Disease...) :
Human
TOLLIP regulates TLR2 and
TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis
Byun et al., Biochem Biophys Res Commun 2013
:
Quercetin markedly elevated the expression of the
Toll interacting protein , a negative
regulator of
TLR signaling