Gene interactions and pathways from curated databases and text-mining

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TLR4 — TOLLIP

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Zhang et al., J Biol Chem 2002 : Negative regulation of TLR signaling by Tollip may therefore serve to limit the production of proinflammatory mediators during inflammation and infection
Li et al., Mol Immunol 2004 : Our study provides yet another mechanism for suppressing excessive TLR signaling activation mediated by Tollip
Zhang et al., Infect Immun 2005 (Pseudomonas Infections) : We also determined that MyD88, IRAK, TRAF6, and Toll interacting protein (Tollip) , but not TIRAP, were involved in the TLR mediated response to P. aeruginosa in HAECs
Hong Byun et al., J Immunol 2010 : Interestingly, EGCG induced a rapid upregulation of Toll interacting protein (Tollip) , a negative regulator of TLR signaling, and this EGCG action was prevented by 67LR silencing or anti-67LR Ab treatment ... RNA interference mediated silencing of Tollip impaired the TLR4 signaling inhibitory activity of EGCG
Byun et al., FEBS Lett 2011 (MAP Kinase Signaling System) : Silencing of Toll interacting protein (Tollip) , a negative regulator of TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip
Shah et al., J Immunol 2012 (Genetic Predisposition to Disease...) : Human TOLLIP regulates TLR2 and TLR4 signaling and its polymorphisms are associated with susceptibility to tuberculosis
Byun et al., Biochem Biophys Res Commun 2013 : Quercetin markedly elevated the expression of the Toll interacting protein , a negative regulator of TLR signaling