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IFNG — TPO

Text-mined interactions from Literome

Wolber et al., J Interferon Cytokine Res 2002 (Carcinoma, Hepatocellular...) : Our results show that IFN-alpha, IFN-beta, or IFN-gamma did not impair TPO mRNA expression, as determined by quantitative RT-PCR, even when high IFN doses ( up to 5000 U/ml ) or long-term incubations ( up to 14 days ) were applied
Guo et al., Endocrinology 2005 : However, as with higher-dose TPO-Ad immunization, T cell epitopes ( assessed by splenocyte interferon-gamma response to TPO in vitro ) were highly diverse and variable in different animals
Ashizawa et al., J Clin Endocrinol Metab 1989 : 1 U/mL IFN-gamma caused maximal suppression of TSH stimulated TPO mRNA levels to basal levels ... IFN-gamma also inhibited 8-bromo-cyclic AMP stimulated TPO mRNA levels ... These results demonstrate that IFN-gamma directly inhibits TSH stimulated TPO gene expression and provide further support for a role of IFN-gamma as a local modulator of thyroid hormone synthesis
Aguayo et al., Autoimmunity 1989 : IFN-gamma at 200 units per ml induced HLA-DR expression, but did not induce thyrocyte TPO expression, or Tg release
Tang et al., Endocrinology 1995 : In the present study, we used FRTL5 cells, a cultured rat thyroid follicular cell line, to examine the effects of IFN-gamma and TNF-alpha on type I 5'-deiodinase ( 5'D-I ) activity and 5'D-I, thyroid peroxidase (TPO) and thyroglobulin (Tg) gene expression ... We also examined the effect of IFN-gamma and TNF-alpha on TPO and Tg gene expression ... As observed with 5'D-I mRNA levels, there was a synergistic effect of IFN-gamma and TNF-alpha on the inhibition of basal and TSH stimulated TPO and Tg gene expression
Chiovato et al., J Clin Endocrinol Metab 1994 (Thyroiditis, Autoimmune) : IFN gamma , either recombinant or produced by T-cell clones, induced HLA-DR appearance in thyrocytes, whereas TSH or TSab stimulated TPO expression