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IL17A — TRAF3IP2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Qian et al., Nat Immunol 2007
(Autoimmune Diseases...) :
We report here the essential
involvement of the adaptor protein
Act1 in
IL-17 receptor (IL-17R) signaling and IL-17 dependent immune responses
Lindén et al., Science's STKE : signal transduction knowledge environment 2007
:
A
role for the cytoplasmic adaptor protein
Act1 in mediating
IL-17 signaling
Huang et al., J Immunol 2007
:
Requirement for both JAK mediated PI3K signaling and
ACT1/TRAF6/TAK1 dependent NF-kappaB
activation by
IL-17A in enhancing cytokine expression in human airway epithelial cells
Peric et al., J Immunol 2008
(MAP Kinase Signaling System...) :
These results suggest that increased
IL-17A in psoriatic skin
increases cathelicidin through a vitamin D ( 3 ) -,
Act1- , and MEK-ERK dependent mechanism
Swaidani et al., J Immunol 2009
(Eosinophilia...) :
The critical
role of epithelial derived
Act1 in
IL-17- and IL-25 mediated pulmonary inflammation
Bulek et al., Nat Immunol 2011
(Pneumonia) :
IKKi was required for
IL-17 induced phosphorylation of
Act1 on Ser311, adjacent to a putative TRAF binding motif
Shi et al., Science signaling 2011
:
Here, we report that persistent stimulation of HeLa cells with
IL-17 resulted in degradation of
Act1 and desensitization of IL-17R signaling
Qu et al., Mol Cell Biol 2012
:
IL-17 stimulation activated TBK1 and
induced its association with
Act1 ... Interestingly, TRAF6, but not TRAF3, which is the upstream adaptor of the IKK related kinases in antiviral signaling, was critical for
IL-17 induced
Act1 phosphorylation ... TRAF6 was essential for
IL-17 induced TBK1 activation, its association with
Act1 , and consequent Act1 phosphorylation