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CREB5 — TRH
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Luo et al., Brain Res 1999
:
To determine whether c-fos/c-jun ( AP-1 ) and
CREB mediate glucocorticoid stimulated
TRH gene regulation, we investigated the effect of N-ethyl-maleimide ( NEM ), an alkylating agent, and 12-O-tetradecanoylphorbol-13-acetate ( TPA ) on this process
Sarkar et al., Brain Res 2002
:
These data demonstrate that i.c.v. alpha-MSH administration increases the phosphorylation of CREB in several subdivisions of the PVN including TRH and CRH neurons in the medial and periventricular parvocellular subdivisions, suggesting that phosphorylation of
CREB may be
necessary for alpha-MSH induced activation of the
TRH and CRH genes
Chiappini et al., Mol Cell Endocrinol 2013
:
To evaluate the
role of
CREB in
TRH regulation in vivo, we deleted CREB from PVN neurons to generate the CREB1 ( dSIM1 ) mouse