Gene interactions and pathways from curated databases and text-mining

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TP53 — TRIM28

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Wang et al., EMBO J 2005 : Depletion of endogenous KAP1 expression by RNAi stimulates p53 transcriptional activity, sensitizes p53 response to DNA damage, and increases apoptosis ... Therefore, MDM2 interaction with KAP1 contributes to p53 functional regulation
Okamoto et al., Biochem Biophys Res Commun 2006 (Neoplasms) : We examined the role of KAP1 in p53 activation after the treatment of cells with different types of external stresses