McLoughlin et al., Am J Physiol Cell Physiol 2009
:
FoxO1 activation resulted in a significant increase in muscle atrophy F-box (MAFbx)/atrogin-1, muscle-specific RING finger protein 1 ( MuRF-1 ), and Bcl-2 interacting mediator of cell death ( Bim ) gene expression, with no significant increase in Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNip3) gene expression
Reed et al., FASEB J 2012
(Cachexia...) :
Expression of DN FoxO inhibited the increased mRNA levels of atrogin-1, MuRF1 , cathepsin L, and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis