◀ Back to FOXO1
FOXO1 — TXNIP
Text-mined interactions from Literome
Li et al., Biochem Biophys Res Commun 2009
:
Up-regulation of
thioredoxin interacting protein (Txnip) by p38 MAPK and
FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose treated endothelial cells
Kibbe et al., J Biol Chem 2013
:
Moreover,
FOXO1 blocked glucose induced
TXNIP expression and reduced glucose induced ChREBP binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization, suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter ... Moreover,
FOXO1 blocked glucose induced
TXNIP expression and reduced glucose induced ChREBP binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization, suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter ... Together, these results demonstrate that
FOXO1 inhibits beta cell
TXNIP transcription and suggest that FOXO1 confers this inhibition by interfering with ChREBP DNA binding at target gene promoters