Gene interactions and pathways from curated databases and text-mining

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FOXO1 — TXNIP

Text-mined interactions from Literome

Li et al., Biochem Biophys Res Commun 2009 : Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose treated endothelial cells
Kibbe et al., J Biol Chem 2013 : Moreover, FOXO1 blocked glucose induced TXNIP expression and reduced glucose induced ChREBP binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization, suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter ... Moreover, FOXO1 blocked glucose induced TXNIP expression and reduced glucose induced ChREBP binding at the TXNIP promoter without affecting ChREBP expression or nuclear localization, suggesting that FOXO1 may compete with ChREBP for binding to the TXNIP promoter ... Together, these results demonstrate that FOXO1 inhibits beta cell TXNIP transcription and suggest that FOXO1 confers this inhibition by interfering with ChREBP DNA binding at target gene promoters