Gene interactions and pathways from curated databases and text-mining

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TGFA — TYMP

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: TYMP → TGFA (increases) Ueda et al., Jpn J Cancer Res 1998*
    Evidence: The sensitivity of tumor cells to 5'-dFUrd depends on the PyNPase activity of the cells, the enzyme expression of OMC-3 cells treated for 48 h with sex steroids or growth factors was measured. The dThdPase expression of tumor cells was increased up to 1.73-fold by 0.1-10 nM EGF and TGFA in a concentration-dependent manner, whereas 17-beta estradiol and progesterone did not have any significant effect on this enzyme.