Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK13

MAPK13 — UCN

Text-mined interactions from Literome

Grammatopoulos et al., Mol Endocrinol 2000 (MAP Kinase Signaling System) : We therefore hypothesized that activation of MAPK might mediate CRH and or/urocortin actions in the myometrium ... The R1alpha and R2beta, but not the R1beta, R1c, or R1d, receptor subtypes were able to mediate urocortin induced MAPK activation ... In conclusion, UCN acting thought multiple receptor subtypes can stimulate myometrial MAPK via induction of the Gq/phospholipase C/IP3/PKC pathway, whereas CRH induced activation of this pathway appears to be insufficient to achieve MAPK activation
Dai et al., Cancer Res 2001 (Leukemia...) : Coadministration of the MEK inhibitor PD184352 ( 10 microM ) blocked UCN-01 induced MAPK activation and was accompanied by marked mitochondrial damage ( e.g., cytochrome c release and loss of DeltaPsi ( m ) ), caspase activation, DNA fragmentation, and apoptosis
Schulman et al., Am J Physiol Heart Circ Physiol 2002 (Hypotension...) : Urocortin attenuated lethal reperfusion induced injury both in vitro and in vivo via a p42/p44 MAPK dependent mechanism
McKinstry et al., Cancer Biol Ther 2002 (Breast Neoplasms...) : Inhibition of MEK1/2 caused modest reductions in basal MAPK activity and transiently suppressed UCN-01 stimulated MAPK activity below that of MEK1/2 inhibitor alone
Punn et al., Mol Endocrinol 2006 : In human embryonic kidney 293 cells overexpressing recombinant CRH-R1alpha, UCN I induced ERK1/2 and p38 MAPK activation was dependent on signaling molecules involved in agonist induced CRH-R1alpha trafficking and endocytosis ... UCN I effect on p38 MAPK phosphorylation was more transient, returned to basal within 40 min and was dependent on epidermoid growth factor receptor transactivation, but not PI3-K/Akt activation