Gene interactions and pathways from curated databases and text-mining

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CRH — UCN3

Text-mined interactions from Literome

Huising et al., Endocrinology 2011 (Insulinoma) : Ucn 3 activates the CRF type-2 receptor ( CRFR2 ) but does not activate the type-1 receptor ( CRFR1 ), which was recently demonstrated on ß-cells
Takahashi et al., International journal of endocrinology 2012 : We have shown that urocortin 1 and urocortin 3 are endogenously synthesized in the myocardial cells of human heart and may act on CRF type 2 receptor ( CRFR2 ) expressed in the heart
Chitravanshi et al., Am J Physiol Regul Integr Comp Physiol 2012 (Bradycardia) : These results indicated that activation of CRF2Rs in the nAmb by UCN3 elicited bradycardia, which was vagally mediated