Gene interactions and pathways from curated databases and text-mining

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CXCL2 — VEGFA

Text-mined interactions from Literome

Darash-Yahana et al., FASEB J 2004 (Adenocarcinoma...) : In vitro, CXCL12 induced the proliferation and VEGF secretion but not migration of PC3 and 22Rv1 cells overexpressing CXCR4
Hosokawa et al., Clin Exp Immunol 2005 (Periodontal Diseases) : Moreover, CXCL12 induced vascular endothelial growth factor ( VEGF ) production by HGF
Brand et al., Exp Cell Res 2005 (Colorectal Neoplasms...) : Moreover, CXCL12 increases vascular endothelial growth factor ( VEGF ) expression and cell proliferation but has no effect on CRC apoptosis
Yao et al., J Neurooncol 2008 (Disease Models, Animal...) : In this study, we examined the capacity of FPR to regulate the production of another angiogenic factor, the chemokine IL-8 ( CXCL8 ), in addition to its demonstrated ability to induce VEGF secretion by malignant glioma cells
Martin et al., J Biol Chem 2009 : CXCL8/IL8 stimulates vascular endothelial growth factor ( VEGF ) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM ( Carma3/Bcl10/Malt1 ) complex ... Furthermore, we identified the components of the CBM complex, Carma3, Bcl10, and Malt1, as key mediators of the CXCL8/IL8 induced NFkappaB activation and VEGF up-regulation ... Together, these findings support the existence of an NFkappaB mediated pathway by which the proinflammatory chemokine CXCL8/IL8 controls the expression of VEGF in endothelial cells, thereby promoting the activation of VEGF receptors in an autocrine fashion