◀ Back to MMP2

MMP2 — VEGFA

Pathways - manually collected, often from reviews:

• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → VEGFA (activation)
• WikiPathways Angiogenesis: PDGFB/MMP9/VEGFA/MMP2/ANGPT1/FGF2 → MMP2/MMP9 (activation)

Text-mined interactions from Literome

Tanaka et al., Jpn J Cancer Res 1999 (Adenocarcinoma...) : Since MMP-1, MMP-3 and MMP-9 play important roles in tumor invasion and TGF-beta and VEGF are involved in tumor angiogenesis, hypothemycin is considered to be an example of a new class of antitumor drugs, whose antitumor efficacy can be at least partly attributed to inhibition of Ras-inducible genes
Nayak et al., J Clin Endocrinol Metab 2000 (Substance Withdrawal Syndrome) : Because of reports that VEGF can enhance MMP expression, we hypothesize that VEGF-KDR interactions may influence MMP expression in the superficial zones of the primate endometrium during the premenstrual phase, and that these interactions play a role in the induction of menstruation
Chae et al., Arterioscler Thromb Vasc Biol 2000 (Disease Models, Animal) : Ang1 or VEGF induced migration and sprouting activity, increased plasmin and matrix metalloproteinase-2 secretion, and decreased tissue inhibitors of metalloproteinase type 2 secretion
Etoh et al., Cancer Res 2001 (Neovascularization, Pathologic...) : MMP-1, MMP-9 , and urokinase-type plasminogen activator in ECs were strongly up-regulated by Ang-2 in the presence of VEGF in vitro
Brenner et al., Ann N Y Acad Sci 2002 (Endometriosis) : A unique role of VEGF at this stage of the cycle may be to stimulate MMP expression in stromal cells because VEGF, KDR, and MMPs were all coordinately induced in these cells in the superficial zone of the primate endometrium by P withdrawal
Lu et al., Zhonghua Fu Chan Ke Za Zhi 2002 (Neoplasm Invasiveness...) : The expression of VEGF correlates to the in vitro invasion of ovarian tumor cell and induction of MMP-2 by VEGF is a key component of VEGF induced ovarian tumor cell invasion
Rivilis et al., Am J Physiol Heart Circ Physiol 2002 : We observed that MMP-2 regulation occurs independent of VEGF signaling, because VEGF did not induce MMP-2 production or activation in isolated endothelial cells
Hotz et al., J Gastrointest Surg 2003 (Disease Models, Animal...) : Blockade of vascular endothelial growth factor ( VEGF ) and inhibition of matrix metalloproteinases ( MMP ) are promising therapies for cancer ... Both VEGF blockade and MMP inhibition reduce primary tumor size, metastasis, and angiogenesis, thereby increasing survival in experimental pancreatic cancer
Kim et al., J Cell Biochem 2003 (Neovascularization, Pathologic) : The stimulation of serum starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( VEGF/bFGF ) caused marked increase in MMP-1 production and induced the pro-MMP-2 activation accompanied by the increase in MT1-MMP expression ... However, pretreatment with flavonoids before VEGF/bFGF stimulation completely abolished the VEGF/bFGF stimulated increase in MMP-1 and MT1-MMP expression and pro-MMP-2 activation ... In conclusion, these data suggest that genistein, apigenin, and 3-hydroxyflavone inhibit in vitro angiogenesis, in part via preventing VEGF/bFGF induced MMP-1 and uPA expression and the activation of pro-MMP-2 , and via modulating their inhibitors, TIMP-1 and -2, and PAI-1
Belotti et al., Cancer Res 2003 (Ascites...) : Exogenous, activated MMP9, and, to a lesser extent, MMP2 , increased VEGF release by SKOV3 and OVCAR3 ovarian carcinoma cells
Arisato et al., Journal of thrombosis and haemostasis : JTH 2003 (Thrombosis) : Gelatinase A , which is closely associated with vascular remodeling, enhances the VEGF levels released from platelets
Suñer et al., Invest Ophthalmol Vis Sci 2004 (Choroidal Neovascularization...) : Nicotine also reversed VEGF induced suppression of MMP-2 activity
Pufe et al., J Pathol 2004 (Osteoarthritis) : VEGF increased secreted MMP-1, MMP-3 , and especially MMP-13, which could be effectively reduced by an inhibitor of VEGFR-2 kinase activity
Oh et al., Cancer Res 2004 (Melanoma) : First, TIMP-2 can inhibit cell migration after VEGF stimulation by direct inhibition of MMP activity induced in response to VEGF stimulation
Yoshiji et al., Gut 2005 (Liver Neoplasms, Experimental...) : Ang-2 plus VEGF overexpression significantly increased the activities of matrix metalloproteinase (MMP)-2 and MMP-9 in the tumour
Notari et al., Invest Ophthalmol Vis Sci 2005 (Anoxia...) : MMP induction by VEGF was performed in baby hamster kidney ( BHK ) cells
Onisto et al., Int J Oncol 2005 (Neoplasm Invasiveness...) : Overall, our data suggest that a high level of MMP-2 protein and VEGF/VEGFR expression may contribute to the metastatic phenotype of ARMS cells and that exogenously induced PAX3-FKHR expression increases MMP-2 secretion and invasive capability of RMS cells
Wang et al., Int J Cancer 2006 (Carcinoma...) : Using Western blotting, we show that VEGF , at 20-80 ng/ml, induced secretion of pro-MMP-7 and pro-MMP-9 and activation of pro-MMP-2 in DOV13 conditioned medium in a concentration dependent manner ... In addition to the effect on MMP secretion/activation, VEGF stimulated secretion of TIMP-2 ; and blocking TIMP-2 activity by an anti-TIMP-2 MAb significantly increased VEGF ( 80 ng/ml ) -induced DOV13 invasion ( p < 0.05 ), suggesting that VEGF may regulate MMP-2 activity in DOV13 conditioned medium through TIMP-2
Lamy et al., Int J Cancer 2006 (Neovascularization, Pathologic...) : Finally, PCK3145 inhibited in vitro EC tubulogenesis and VEGF induced MMP-2 secretion suggesting its potential implication as an antiangiogenic agent
Kwon et al., Exp Dermatol 2007 : TAPS significantly inhibited VEGF induced proteolytic enzyme production, including matrix metalloproteinase-2 , urokinase-type plasminogen activator and plasminogen activator inhibitor-1
Zhang et al., Zhonghua Xue Ye Xue Za Zhi 2007 : As2 O3 may down-regulate the expression of VEGF and inhibit the activity of MMP-2 and 9
Hollborn et al., Invest Ophthalmol Vis Sci 2007 : Exogenous MMP-9 increased the gene expression and secretion of VEGF, whereas MMP-2 reduced the secretion of VEGF
Adya et al., Cardiovasc Res 2008 : Inhibition of VEGFR2 and VEGF [ by soluble FMS-like tyrosine kinase-1 ( sFlt1 ) ] down-regulated visfatin induced MMP induction
Kim et al., J Neurosci 2008 : Moreover, isolated adult canary forebrain endothelial cells secreted MMP2 , and VEGF substantially increased endothelial MMP2 gelatinase activity ... To assess the importance of androgen regulated , VEGF induced MMP2 to adult angiogenesis and neurogenesis, we treated testosterone implanted females with the gelatinase inhibitor SB-3CT
Cezar-de-Mello et al., Br J Pharmacol 2008 (Neovascularization, Pathologic) : Because the transcription factor NF-kappaB has been implicated in VEGF mediated MMP expression and EC proliferation, we postulated that ATL-1 might modulate the NF-kappaB pathway and, indeed, ATL-1 inhibited NF-kappaB nuclear translocation
Ispanovic et al., Am J Physiol Cell Physiol 2008 : Furthermore, VEGF dependent activation of MMP-2 was reduced by inhibition of Cdc42
Wang et al., Arterioscler Thromb Vasc Biol 2009 : Depletion of GIT1 by siRNA also significantly inhibited VEGF induced MMP2 activation and extracellular matrix ( ECM ) degradation ... Therefore, GIT1 mediates VEGF induced matrix metalloproteinase ( MMP ) activation and ECM degradation by regulating podosome formation
Park et al., Vascul Pharmacol 2009 : Such antiangiogenic activity correlated with suppression of VEGF induced matrix metalloproteinase (MMP)-2 expression, reactive oxygen species ( ROS ) production, and extracellularly regulated kinase (ERK) phosphorylation
Göoz et al., Biochem Biophys Res Commun 2009 : In mechanistic studies, both baseline and VEGF induced MMP-2 activation and Matrigel invasion were inhibited by ADAM-17 depletion
Lee et al., Stroke 2009 (Neovascularization, Pathologic) : Both specific and nonspecific inhibition of nitric oxide synthase resulted in similar reductions, suggesting that VEGF stimulated cerebral MMP activity and angiogenesis are predominantly mediated through inducible nitric oxide synthase, a specific nitric oxide synthase isoform mediating inflammatory responses
Kang et al., Clin Exp Pharmacol Physiol 2009 (Diabetes Mellitus, Experimental...) : Impairment of ischaemia induced EPC mobilization in the diabetic mouse model is associated with altered HIF-1 alpha/VEGF and MMP/TIMP regulation and represents a novel mechanism underlying defective postischaemic neovascularization in diabetes
Park et al., J Pharmacol Sci 2009 : The antiangiogenic activity of TROG correlated with suppression of VEGF induced matrix metalloproteinase (MMP)-2 and membrane type 1 (MT1)-MMP expression ... In addition, the effects of TROG on VEGF induced MMP-2 and MT1-MMP expression were comparable to those of the NADPH oxidase inhibitor diphenylene iodium ( 10 muM ) and ERK inhibitor PD98056 ( 10 muM )
Wu et al., Journal of thrombosis and haemostasis : JTH 2010 : As detected by gelatinolytic activity assay, VEGF stimulated secretion and activation of matrix metallopeptidase 2 (MMP-2) , but not MMP-9, in the conditioned medium of 3D culture of EPCs
Chetty et al., Int J Cancer 2010 (Lung Neoplasms) : In summary, these data provide new insights into the mechanisms underlying MMP-2 mediated VEGF expression in lung tumor angiogenesis
Woenne et al., Anticancer Res 2010 (Carcinoma, Squamous Cell...) : MMP inhibition blocks fibroblast dependent skin cancer invasion, reduces vascularization and alters VEGF-A and PDGF-BB expression
Lucas et al., Oncogene 2010 (Carcinoma, Squamous Cell...) : HEF1 silencing and overexpression studies revealed a role for VEGF in regulating cell migration, invasion and matrix metalloproteinase ( MMP ) expression in a HEF1 dependent manner
Hoffmann et al., Biochem Pharmacol 2011 (Adenocarcinoma...) : Proinflammatory IL-6 and PGHS-2 as well as proangiogenic IL-8 and VEGF were induced by IL-1, whereas the secretion of invasion promoting MMP-2 remained unaffected
Wang et al., Arch Oral Biol 2012 (Neovascularization, Pathologic...) : Compared to their age matched controls, the protein levels of VEGF and CTGF were higher in 20-week experimental group, and the protein and mRNA levels of CTGF, MMP-9 , and CHM-I increased in the 24-week experimental group ( all P < 0.05 )
Kim et al., IUBMB Life 2012 : UK1 also suppressed VEGF165 induced activation of MMP-2
Ghosh et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : VEGF induced the expression of MMP-2, MMP-9 , and MMP-13 and hence regulated the metastasis of SKOV-3 ovarian cancer cells, and the activities of these MMPs were reduced after inhibition of PI3K/AKT and p38 MAPK pathways
Guo et al., Cytotechnology 2012 : To evaluate the effect of GFP on the paracrine actions of BM-MSCs, Western blot analysis was performed to detect the expression of vascular endothelial growth factor ( VEGF ), b fibroblast growth factor (b FGF), tissue inhibitor of metalloproteinase-1 ( TIMP-1 ) and matrix metalloproteinases-2 (MMP-2)
Bandyopadhyay et al., Invest Ophthalmol Vis Sci 2012 (Retinal Neovascularization) : Inhibition of MMP-2/9 activity increased PEDF and decreased VEGF levels in the apical and basal supernatants but had no effect on their expression levels
Kudo et al., J Biol Chem 2012 (Head and Neck Neoplasms...) : Interestingly, MMP-13 promoted the secretion of VEGF-A from fibroblasts and endothelial cells
Gao et al., Ann Rheum Dis 2013 (Arthritis, Psoriatic...) : Finally, DAPT significantly decreased VEGF/Ang2 induced IL-6, IL-8, MMP2 and 9 expressions in RA synovial explants
Pratheeshkumar et al., PloS one 2012 (Neoplasm Invasiveness...) : Western blot analysis showed that luteolin suppressed VEGF induced phosphorylation of VEGF receptor 2 and their downstream protein kinases AKT, ERK, mTOR, P70S6K, MMP-2 , and MMP-9 in HUVECs
Chen et al., Nan Fang Yi Ke Da Xue Xue Bao 2013 : MMP-2/MMP-9 inhibitor III did not obviously affected the expression of PTEN, VEGF or Flk-1 as compared with the non transfected or empty vector transfected cells
Stack et al., Am J Vet Res 2013 : Pulmonary veins were isolated, and a quantitative real-time PCR assay was used to determine mRNA expression of matrix metalloproteinase-2 and -9, tissue inhibitor of metalloproteinase-1 and -2, collagen type I, tenascin-C, endothelin-1, platelet derived growth factor, transforming growth factor ( TGF ) -ß, and vascular endothelial growth factor ( VEGF )
Zucker et al., Int J Cancer 1998 (Neovascularization, Pathologic) : VEGF/VPF also directly increased HUVEC secretion of interstitial collagenase, tissue inhibitor of metalloproteinases ( TIMP-1 ) and, to a lesser extent, gelatinase A ... We propose that an early step in tumor angiogenesis involves VEGF induced thrombin generation and increased MMP production with subsequent activation of endothelial progelatinase A and degradation of the underlying basement membrane
Wang et al., Circ Res 1998 : These data suggest the role of flt-1 in mediating VEGF stimulated MMP expression of SMCs