Gene interactions and pathways from curated databases and text-mining

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PRKACB — VEGFA

Text-mined interactions from Literome

Amano et al., Jpn J Pharmacol 2001 : These results suggested that AC/PKA dependent induction of VEGF certainly enhanced angiogenesis and that pharmacological tools for controlling this signaling pathway may be able to facilitate the management of conditions involving angiogenesis
Amano et al., Hum Cell 2002 : These results suggested that COX-2 and AC/PKA dependent induction of VEGF certainly enhanced angiogenesis, and that pharmacological tools for controlling this signaling pathway may be able to facilitate the management of conditions involving angiogenesis
Anand et al., Biol Reprod 2003 (MAP Kinase Signaling System) : Gonadotropin stimulated VEGF production was mediated by cAMP dependent protein kinase A (PKA) , as evidenced by the effect of hCG being mimicked by 8Br-cAMP and being abolished in the presence of a PKA-specific inhibitor, H-89
Jeon et al., Mol Cells 2007 : These results indicate that PKA phosphorylates CREB and so induces VEGF gene expression
Atsuta et al., Int J Cardiol 2009 : Experiments using various pharmacological inhibitors for protein kinases showed that activation of cAMP dependent protein kinase (PKA) was involved in BPS mediated regulation of VEGF and PAI-1 mRNA expression
Namkoong et al., Cell Signal 2009 : Forskolin increases angiogenesis through the coordinated cross-talk of PKA dependent VEGF expression and Epac mediated PI3K/Akt/eNOS signaling ... These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA dependent VEGF expression and Epac dependent ERKactivation and PI3K/Akt/eNOS/NO signaling
Al-Wadei et al., Anticancer Drugs 2009 (Carcinoma, Pancreatic Ductal...) : Our data suggest that propranolol may prevent the development of PDAC by blocking cAMP dependent intracellular signaling, cAMP dependent release of epidermal growth factor, and PKA dependent release of vascular endothelial growth factor while additionally downregulating the alpha7 nAChR by inhibiting cAMP mediated subunit assembly
Spirli et al., Gastroenterology 2010 (Cysts...) : Inhibition of protein kinase A (PKA) reduced VEGF secretion and pERK1/2 expression
Yates-Binder et al., PloS one 2012 : Inhibition of endothelial function by IP-10p was similar to that described for IP-10, secondary to CXCR3 mediated increase in cAMP production, activation of PKA inhibiting cell migration, and inhibition of VEGF mediated m-calpain activation
Cheng et al., Invest Ophthalmol Vis Sci 1998 : The inductions of VEGF and bFGF mRNA expression by PGE2 were blocked by the specific PKA inhibitors H-89 ( 30 microM ) or SQ 22536 ( 500 microM, 1000 microM )