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IFNG — VIP
Text-mined interactions from Literome
Delgado et al., J Neuroimmunol 1999
(Endotoxemia) :
VIP/PACAP inhibit the production of IL-12, IL-6, tumor necrosis factor alpha (TNFalpha), and
interferon gamma (IFNgamma) in vivo in endotoxemic mice
Kang et al., Ann Allergy Asthma Immunol 2000
(Dermatitis, Atopic) :
Effects of substance P and
vasoactive intestinal peptide on
interferon-gamma and interleukin-4 production in severe atopic dermatitis ... The study was designed to examine the
effects of SP and
VIP on the production of
IFN-gamma and IL-4 ... The
effects of SP and
VIP on the production of
IFN-gamma and IL-4 in phytohemagglutinin stimulated PBMC cultures over a 48-hour period were analyzed by enzyme linked immunosorbent assay in 15 AD patients ... Although
VIP had no specific noticeable effects on the
IFN-gamma and IL-4 production
Voice et al., J Immunol 2003
(Hypersensitivity, Delayed...) :
Dependence of the Th phenotype of T mice, but not of N or K mice, on T cell derived VIP now is proven by showing that eliminating
VIP from TCR stimulated T cell cultures with VIPase IgG normalizes the elevated number of IL-4 secreting CD4 T cells, decreases the secretion of IL-4 and IL-10, and
increases the secretion of
IFN-gamma
Kulka et al., Immunology 2008
:
VIP , SP and compound 48/80 also
activated release of tumour necrosis factor, IL-3 and granulocyte-macrophage colony stimulating factor, but not IL-4,
interferon-gamma or eotaxin
Abdalla et al., Iran J Immunol 2008
:
Gastrin, secretin, GIP and
VIP increased IL-2 and
IFN- gamma levels under some culture conditions and depressed IL-2 under other conditions
Luo et al., Eur J Pharmacol 2009
(Disease Models, Animal...) :
Meanwhile,
VIP significantly
inhibited the release of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and
interferon-gamma (IFN-gamma) in concanavalin A-injected mice, but markedly elevated the production of anti-inflammatory cytokine interleukine-10 (IL-10)
Muscettola et al., Immunobiology 1990
:
Somatostatin and
vasoactive intestinal peptide reduce
interferon gamma production by human peripheral blood mononuclear cells ... In this study, we describe the
effect of somatostatin (SOM) and
vasoactive intestinal peptide (VIP) on
interferon gamma (IFN-gamma) production by normal human peripheral blood mononuclear cells ( PBMC ) stimulated in vitro with polyclonal T cell activator staphylococcal enterotoxin A (SEA) ... Our findings provide experimental evidence that both SOM and
VIP reduce the
IFN-gamma production by SEA stimulated PBMC ... The meaning of inhibitory
effect of
VIP and SOM on
IFN-gamma production and its role in immune response in vivo are discussed
Taylor et al., J Immunol 1994
(Hypersensitivity, Delayed) :
At this intraocular concentration,
VIP suppressed Ag-stimulated lymph node cell ( LNC ) proliferation and
IFN-gamma production in vitro
Ganea et al., J Neuroimmunol 1993
:
In contrast with its effect on IL-2,
VIP did not
affect IFN gamma production by either mitogen stimulated normal T lymphocytes, or by the L12R4 murine T cell line which produces IFN gamma in response to PMA stimulation
Tang et al., J Interferon Cytokine Res 1995
:
Both
VIP and Ro 25-1553
inhibit IL-2 and IL-4 but not
IFN-gamma production and induce intracellular cAMP
Bondesson et al., Acta Derm Venereol 1996
(Dermatitis, Allergic Contact) :
The effect of
VIP is possibly
mediated by an increased production of
interferon gamma
Kawamura et al., Neuroimmunomodulation 1998
:
We investigated the
effects of neuropeptide Y (NPY), calcitonin gene related peptide (CGRP), substance P ( SP ) and
vasoactive intestinal peptide (VIP) on the production of
interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) by stimulating nonadherent splenocytes and helper T cell clones with antigens in vitro in the presence or absence of these peptides ... SP and
VIP had no effects on
IFN-gamma production, but SP enhanced and VIP suppressed IL-4 production slightly but consistently