Gene interactions and pathways from curated databases and text-mining

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IFNG — VIP

Text-mined interactions from Literome

Delgado et al., J Neuroimmunol 1999 (Endotoxemia) : VIP/PACAP inhibit the production of IL-12, IL-6, tumor necrosis factor alpha (TNFalpha), and interferon gamma (IFNgamma) in vivo in endotoxemic mice
Kang et al., Ann Allergy Asthma Immunol 2000 (Dermatitis, Atopic) : Effects of substance P and vasoactive intestinal peptide on interferon-gamma and interleukin-4 production in severe atopic dermatitis ... The study was designed to examine the effects of SP and VIP on the production of IFN-gamma and IL-4 ... The effects of SP and VIP on the production of IFN-gamma and IL-4 in phytohemagglutinin stimulated PBMC cultures over a 48-hour period were analyzed by enzyme linked immunosorbent assay in 15 AD patients ... Although VIP had no specific noticeable effects on the IFN-gamma and IL-4 production
Voice et al., J Immunol 2003 (Hypersensitivity, Delayed...) : Dependence of the Th phenotype of T mice, but not of N or K mice, on T cell derived VIP now is proven by showing that eliminating VIP from TCR stimulated T cell cultures with VIPase IgG normalizes the elevated number of IL-4 secreting CD4 T cells, decreases the secretion of IL-4 and IL-10, and increases the secretion of IFN-gamma
Kulka et al., Immunology 2008 : VIP , SP and compound 48/80 also activated release of tumour necrosis factor, IL-3 and granulocyte-macrophage colony stimulating factor, but not IL-4, interferon-gamma or eotaxin
Abdalla et al., Iran J Immunol 2008 : Gastrin, secretin, GIP and VIP increased IL-2 and IFN- gamma levels under some culture conditions and depressed IL-2 under other conditions
Luo et al., Eur J Pharmacol 2009 (Disease Models, Animal...) : Meanwhile, VIP significantly inhibited the release of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) in concanavalin A-injected mice, but markedly elevated the production of anti-inflammatory cytokine interleukine-10 (IL-10)
Muscettola et al., Immunobiology 1990 : Somatostatin and vasoactive intestinal peptide reduce interferon gamma production by human peripheral blood mononuclear cells ... In this study, we describe the effect of somatostatin (SOM) and vasoactive intestinal peptide (VIP) on interferon gamma (IFN-gamma) production by normal human peripheral blood mononuclear cells ( PBMC ) stimulated in vitro with polyclonal T cell activator staphylococcal enterotoxin A (SEA) ... Our findings provide experimental evidence that both SOM and VIP reduce the IFN-gamma production by SEA stimulated PBMC ... The meaning of inhibitory effect of VIP and SOM on IFN-gamma production and its role in immune response in vivo are discussed
Taylor et al., J Immunol 1994 (Hypersensitivity, Delayed) : At this intraocular concentration, VIP suppressed Ag-stimulated lymph node cell ( LNC ) proliferation and IFN-gamma production in vitro
Ganea et al., J Neuroimmunol 1993 : In contrast with its effect on IL-2, VIP did not affect IFN gamma production by either mitogen stimulated normal T lymphocytes, or by the L12R4 murine T cell line which produces IFN gamma in response to PMA stimulation
Tang et al., J Interferon Cytokine Res 1995 : Both VIP and Ro 25-1553 inhibit IL-2 and IL-4 but not IFN-gamma production and induce intracellular cAMP
Bondesson et al., Acta Derm Venereol 1996 (Dermatitis, Allergic Contact) : The effect of VIP is possibly mediated by an increased production of interferon gamma
Kawamura et al., Neuroimmunomodulation 1998 : We investigated the effects of neuropeptide Y (NPY), calcitonin gene related peptide (CGRP), substance P ( SP ) and vasoactive intestinal peptide (VIP) on the production of interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) by stimulating nonadherent splenocytes and helper T cell clones with antigens in vitro in the presence or absence of these peptides ... SP and VIP had no effects on IFN-gamma production, but SP enhanced and VIP suppressed IL-4 production slightly but consistently