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INS — VIP
Text-mined interactions from Literome
Adeghate et al., Peptides 2001
(Diabetes Mellitus, Experimental) :
Moreover, the
effect of
VIP , NPY and SP on
insulin secretion from the pancreas of normal and diabetic rats was also examined ... In summary,
VIP and NPY can
stimulate insulin secretion from the pancreas after the onset of diabetes
Andersson et al., Regul Pept 1992
(Insulinoma...) :
VIP caused a dose dependent increase in cAMP-formation in both m5F and 14B cell membranes with EC50 values of 3.0 and 3.5 nM, respectively, but VIP ( 1.10 ( -9 ) -3.10 ( -6 ) M )
had no effect on
insulin secretion ( over 2 h ) from the m5F cells
Salehi et al., Regul Pept 2004
:
The
role of PACAP27, PACAP38 and
VIP in the regulation of
insulin release from pancreatic islets isolated from rats previously subjected to total parenteral nutrition (TPN) for 10 days was studied
Persson-Sjögren et al., Neuropeptides 2006
:
Both
VIP and PACAP
enhanced insulin secretion in islets from 4-week-old hyperglycemic ob/ob mice ...
VIP did not
increase 11.1 mM glucose induced
insulin release in islets from 4-week-old lean normoglycemic mice and neither did PACAP in the absence of bicarbonate ...
VIP increased early phase
insulin release in perifused islets from young mice
Miralles et al., Diabetes 1990
:
Infusion of rat galanin reduced unstimulated insulin release ( approximately 60 %, P less than 0.01 ) and the
insulin responses to arginine ( approximately 30 %, P less than 0.025 ), glucose ( 100 %, P less than 0.01 ), and
VIP ( approximately 80 %, P less than 0.025 )
Winzell et al., Peptides 2007
:
VIP and PACAP
stimulate insulin secretion in a glucose dependent manner and they both also stimulate glucagon secretion
Ahrén et al., Regul Pept 1991
:
Effects of helodermin and
VIP on
insulin and glucagon secretion in the mouse
Peiró et al., Metabolism 1989
:
Pancreastatin infusion consistently reduced the
insulin responses to
VIP , GIP, and 8-CCK without modifying glucagon or somatostatin release
Ahrén et al., Peptides 1989
:
Since
VIP and PHI both
stimulate insulin and glucagon secretion, we investigated the effects of helodermin on insulin and glucagon secretion in the mouse, both in the basal state and during administration of glucose and the cholinergic agonist carbachol
Gardner et al., Am J Physiol 1985
:
Glucagon and
insulin had no effect on
125I-VIP binding in nonparenchymal cells
Schebalin et al., Am J Physiol 1977
:
Stimulation of
insulin and glucagon secretion by
vasoactive intestinal peptide ... In vivo,
vasoactive intestinal peptide (VIP) produces simultaneous
increases in blood glucose and
insulin levels ... In order to determine whether
VIP , like its homologues, also
stimulates insulin secretion directly, studies were made in controlled glucose media employing the vascularly perfused cat pancreas ...
VIP stimulated
insulin secretion significantly in the presence of constant physiological concentrations of glucose ... The highest
insulin response to
VIP ( 100.3+/-8.1 muU/min ) approached the highest insulin response to glucose ( 119.9 +/- 12.0 muU/min ) ... In the absence of glucose, the
insulin response to
VIP was insignificant
Guo et al., Pancreas 1988
:
Peptide YY ( 400 pmol/kg/h ) depressed the insulin levels in response to GRP or G4 but failed to inhibit bethanechol- and
VIP stimulated
insulin release
Sandberg et al., Acta Endocrinol (Copenh) 1988
:
Gastric inhibitory polypeptide (GIP), cholecystokinin (CCK), and
vasoactive intestinal polypeptide (VIP) stimulate
insulin secretion ... In contrast, 1.0 nmol/l
VIP inhibited
insulin secretion augmented by glucose and GIP ... In summary 1 ) GIP, CCK-33 and VIP all potentiate glucose induced insulin secretion from the perfused rat pancreas, and 2 ) CCK-33 potentiates and
VIP inhibits GIP induced
insulin secretion
Fahrenkrug et al., Regul Pept 1987
:
These levels of
VIP which are above those found in the circulation under physiological conditions
stimulated secretion of
insulin , C-peptide and pancreatic glucagon dose-dependently
Szecówka et al., Diabetologia 1980
:
Vasoactive Intestinal Polypeptide (VIP) increased the release of
insulin , glucagon and somatostatin from the perfused rat pancreas ... VIP stimulated glucagon release in the absence of glucose, while
insulin and somatostatin release were
increased by
VIP only in the presence of glucose concentrations of 4.4 mmol/l and above ... In contrast,
VIP did not
induce any further increase in the secretion of
insulin and somatostatin over that stimulated by arginine
Guerrero et al., Rev Esp Fisiol 1981
:
The specificity of the binding sites of VIP was established from the fact that binding of
125I-VIP was
inhibited by native VIP and by 60-fold higher concentrations of secretin but not by the parent hormone glucagon, by
insulin or somatostatin at concentrations as high as 10 ( -6 ) M
Arilla et al., Horm Metab Res 1981
:
The isolated perfused rat pancreas with duodenal exclusion was used to study the stimulation of glucose induced
insulin release in
response to chicken and porcine
vasoactive intestinal peptide (VIP) ... The
insulin response to 5.5 or 16.7 mM glucose was markedly
enhanced by 750 pM porcine
VIP and a concentration of 250 pM was still effective ... After suppression of VIP and somatostatin from the perfusion medium,
insulin release
increased to levels higher than those with glucose alone in the case of the avian peptide, but not in that porcine
VIP
Hermansen et al., Endocrinology 1980
:
Insulin release was
enhanced by substance P ( 150 +/- 45 % ; P less than 0.05 ), bombesin ( 162 +/- 56 % ; P less than 0.05 ),
VIP ( 44 +/- 5 % ; P less than 0.01 ), and CCK-8-S ( 190 +/- 17 % ; P less than 0.001 )
Inoue et al., Dig Dis Sci 1983
:
The present study demonstrated that synthetic chicken
VIP induces significant increases in pancreatic blood flow, pancreaticobiliary secretion, and blood levels of
insulin and glucose in dogs
Lygren et al., Scand J Gastroenterol 1983
(Hypoglycemia...) :
A significant increase in peripheral plasma VIP was observed when atropine was given together with insulin, whereas
insulin or atropine alone
had no effect on plasma
VIP
Axen et al., Am J Physiol 1982
:
In isolated, perfused ethionine treated pancreases secretin failed to stimulate insulin secretion, whereas basal
insulin secretion and insulin
responses to glucose, arginine, gastric inhibitory polypeptide,
vasoactive intestinal peptide (VIP), and somatostatin were similar to those of controls
Makhlouf et al., Scand J Gastroenterol 1978
:
Comparative
effects of synthetic and natural
vasoactive intestinal peptide on pancreatic and biliary secretion and on glucose and
insulin blood levels in the dog ... Synthetic
VIP also produced a dose dependent
increase in blood glucose levels and a synchronous and proportionate increase in blood
insulin levels ... The
effects of antural
VIP on pancreatic and biliary secretion and on glucose and
insulin blood levels were identical to those of synthetic VIP
Jensen et al., Am J Physiol 1978
:
VIP stimulated the
insulin and glucagon secretion in a dose dependent manner ... In the presence of a glucose concentration of 7.5 mmol/liter,
VIP enhanced
insulin release without affecting glucagon release ... At a glucose concentration of 5.0 or 3.5 mmol/liter,
VIP enhanced glucagon release but not
insulin release
Ahrén et al., Diabetologia 1981
:
Effects of
vasoactive intestinal polypeptide (VIP) , secretin and gastrin on
insulin secretion in the mouse ... The in vivo
effects of
vasoactive intestinal polypeptide (VIP) , secretin and two different molecular forms of gastrin, gastrin 17 and pentagastrin, on basal and stimulated
insulin secretion have been investigated in the mouse ...
VIP and secretin both
potentiated glucose induced
insulin release ... Secretin inhibited insulin secretion induced by carbachol and L-IPNA, whereas
VIP potentiated L-IPNA induced
insulin secretion and had no influence on the effect of carbachol
Kulkarni et al., J Endocrinol 1995
:
A 67 kDa protein mediates pituitary adenylate cyclase activating polypeptide and
vasoactive intestinal peptide stimulated
insulin secretion in a hamster clonal beta-cell line ... We therefore carried out receptor binding studies on membranes prepared from the glucose-responsive clonal beta-cell line HIT-T15, and also examined the
effects of PACAP38, PACAP27 -- a C-terminal truncated form of the peptide -- and
vasoactive intestinal peptide (VIP) on
insulin and islet amyloid polypeptide (IAPP) release ... These findings suggest that PACAP and
VIP stimulate secretion of
insulin and IAPP by binding to a 67 kDa protein on clonal beta-cells and do not alter the transcription of insulin and IAPP under the conditions tested
Kato et al., J Biol Chem 1994
:
These results indicate that
VIP and PHM-27 produced from the transgenic beta cells efficiently
enhance glucose induced
insulin secretion from beta cells by an autocrine mechanism
Straub et al., J Biol Chem 1996
:
The prolonged effects, but not the acute
effects of
VIP and PACAP on
insulin release were inhibited by low concentrations of wortmannin, a phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor ... It is concluded that the acute
stimulation of
insulin release by
VIP and PACAP is mediated by increased cyclic AMP and [ Ca2+ ] i, whereas the sustained release is mediated by a novel wortmannin-sensitive pathway
Belai et al., J Auton Nerv Syst 1996
(Diabetes Mellitus, Experimental) :
Generally, the similarity of
effect of ponalrestat and
insulin on
VIP and galanin expression in this study supports a primary effect of insulin via glycaemic control
Inagaki et al., Ann N Y Acad Sci 1996
:
Furthermore,
insulin secretion from the MIN6 cells is
stimulated significantly by PACAP-38 and
VIP
Kato et al., Ann N Y Acad Sci 1996
(Diabetes Mellitus, Experimental) :
Using transgenic mice technology, it has now become possible to test directly whether
VIP and PHM-27 can
enhance glucose induced
insulin secretion and reduce blood glucose in vivo
Straub et al., Ann N Y Acad Sci 1996
:
VIP and PACAP
stimulate insulin release by interaction with the VIP-2/PACAP-3 receptor on the beta cell ... This third pathway, which is identified at present only by its sensitivity to low concentrations of wortmannin, plays a major role in the prolonged
stimulation of
insulin release by
VIP and PACAP