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BTK — WAS

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: WAS — BTK (physical association, affinity chromatography technology) Morrogh et al., Eur J Immunol 1999*
• IRef Biogrid Interaction: WAS — BTK (direct interaction, pull down) Cory et al., J Immunol 1996*
• IRef Hprd Interaction: WAS — BTK (in vitro) Baba et al., Blood 1999*, Cory et al., J Biol Chem 2002, Torres et al., Mol Cell 2003*, Cory et al., J Immunol 1996*, Guinamard et al., FEBS Lett 1998*
• IRef Hprd Interaction: WAS — BTK (in vivo) Baba et al., Blood 1999*, Cory et al., J Biol Chem 2002, Torres et al., Mol Cell 2003*, Cory et al., J Immunol 1996*, Guinamard et al., FEBS Lett 1998*
• IRef Ophid Interaction: WAS — BTK (aggregation, confirmational text mining) Cory et al., J Immunol 1996*
• IRef Ophid Interaction: WAS — BTK (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Gross et al., Blood 1999 (Wiskott-Aldrich Syndrome) : This indicates that Src kinases, phosphatidylinositol 3-kinase ( PI 3-kinase ), and Btk all contribute to the regulation of tyrosine phosphorylation of WASp
Sharma et al., J Immunol 2009 : Using xid mice and a Btk inhibitor, we show that BCR engagement increases actin polymerization and Wiskott-Aldrich syndrome protein activation in a Btk dependent manner ... Thus, Btk regulates actin dynamics and Ag transport by activating Wiskott-Aldrich syndrome protein via Vav and phosphatidylinositides